HDAC6 (histone deacetylase 6)

2003-11-01  

Identity

HGNC
HDAC6
LOCATION
Xp11.23
LOCUSID
10013
ALIAS
CPBHM,HD6,JM21,PPP1R90
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10013
MIM: 300272
HGNC: 14064
Ensembl: ENSG00000094631

Variants:

dbSNP: 10013
ClinVar: 10013
TCGA: ENSG00000094631
COSMIC: HDAC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000094631ENST00000334136Q9UBN7
ENSG00000094631ENST00000334136A0A024QZ26
ENSG00000094631ENST00000376610A6NDI8
ENSG00000094631ENST00000376619Q9UBN7
ENSG00000094631ENST00000376619A0A024QZ26
ENSG00000094631ENST00000376643A6NDI8
ENSG00000094631ENST00000423941C9J172
ENSG00000094631ENST00000430858H7C0Z9
ENSG00000094631ENST00000438518C9JEF4
ENSG00000094631ENST00000440653E7ER52
ENSG00000094631ENST00000441703Q9BRX7
ENSG00000094631ENST00000443563E7EP63
ENSG00000094631ENST00000461608A0A2R8Y758
ENSG00000094631ENST00000462730Q9BRX7
ENSG00000094631ENST00000465269Q9BRX7
ENSG00000094631ENST00000476625A0A2R8Y5Z4
ENSG00000094631ENST00000480525A0A2R8Y6Z9
ENSG00000094631ENST00000486665A0A2R8YGC5
ENSG00000094631ENST00000489352A0A2R8Y5Z4
ENSG00000094631ENST00000642405A0A2R8Y559
ENSG00000094631ENST00000643374Q9UBN7
ENSG00000094631ENST00000643374A0A024QZ26
ENSG00000094631ENST00000643934A0A2R8YDE6
ENSG00000094631ENST00000644068Q9UBN7
ENSG00000094631ENST00000644068A0A024QZ26
ENSG00000094631ENST00000645643A0A2R8Y4G2
ENSG00000094631ENST00000646703A0A2R8YCS4
ENSG00000094631ENST00000647398A0A2R8YD35

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376651352024Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.3
379493032024Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.0
381995702024HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent.1
383340072024HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.1
386466452024HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.0
376651352024Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.3
379493032024Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.0
381995702024HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent.1
383340072024HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.1
386466452024HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.0
364447972023The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.11
365163382023Anti-microbial host factor HDAC6 is antagonised by the influenza A virus through host caspases and viral PA.4
365782172023HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling.2
366396502023Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction.7
368611432023Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1.0

Citation

Dessen P

HDAC6 (histone deacetylase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40807/hdac6-(histone-deacetylase-6)