HDAC9 (histone deacetylase 9)

2003-05-01  

Identity

HGNC
HDAC9
LOCATION
7p21.1
LOCUSID
9734
ALIAS
HD7,HD7b,HD9,HDAC,HDAC7,HDAC7B,HDAC9B,HDAC9FL,HDRP,MITR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9734
MIM: 606543
HGNC: 14065
Ensembl: ENSG00000048052

Variants:

dbSNP: 9734
ClinVar: 9734
TCGA: ENSG00000048052
COSMIC: HDAC9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000048052ENST00000401921Q9UKV0
ENSG00000048052ENST00000405010Q9UKV0
ENSG00000048052ENST00000406072B5MCF1
ENSG00000048052ENST00000406451Q9UKV0
ENSG00000048052ENST00000413380C9J1W4
ENSG00000048052ENST00000413509C9IZS0
ENSG00000048052ENST00000417496Q9UKV0
ENSG00000048052ENST00000428307Q9UKV0
ENSG00000048052ENST00000430454C9J835
ENSG00000048052ENST00000432645Q9UKV0
ENSG00000048052ENST00000433709C9JLX1
ENSG00000048052ENST00000441542Q9UKV0
ENSG00000048052ENST00000441986C9JD56
ENSG00000048052ENST00000446646F8WDS2
ENSG00000048052ENST00000456174Q9UKV0
ENSG00000048052ENST00000524023Q9UKV0
ENSG00000048052ENST00000622668B7Z3P7

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451846valproic acidChemicalPathwayassociated23407051

References

Pubmed IDYearTitleCitations
375735382024Aberrant expression and regulatory role of histone deacetylase 9 in vascular endothelial cell injury in intracranial aneurysm.1
379398812024CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.0
382183812024HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD.1
384211012024HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.0
384603702024Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.0
384915222024Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.0
385281892024Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.0
375735382024Aberrant expression and regulatory role of histone deacetylase 9 in vascular endothelial cell injury in intracranial aneurysm.1
379398812024CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.0
382183812024HDAC9 inhibition reduces skeletal muscle atrophy and enhances regeneration in mice with cigarette smoke-induced COPD.1
384211012024HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.0
384603702024Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.0
384915222024Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9.0
385281892024Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.0
327580092023Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease.4

Citation

Dessen P

HDAC9 (histone deacetylase 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40808