HSPA1A (heat shock protein family A (Hsp70) member 1A)

2003-08-01

Identity

HGNC

HSPA1A

LOCATION

6p21.33

LOCUSID

3303

ALIAS

HEL-S-103,HSP70-1,HSP70-1A,HSP70-2,HSP70.1,HSP70.2,HSP70I,HSP72,HSPA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3303
MIM: 140550
HGNC: 5232
Ensembl: ENSG00000204389

Variants:

dbSNP: 3303
ClinVar: 3303
TCGA: ENSG00000204389
COSMIC: HSPA1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204389	ENST00000375651	P0DMV8
ENSG00000204389	ENST00000375651	A8K5I0
ENSG00000204389	ENST00000608703	V9GZ37

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Antigen processing and presentation	KEGG	hsa04612
Attenuation phase	REACTOME	R-HSA-3371568
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408
Cellular response to heat stress	REACTOME	R-HSA-3371556
Cellular responses to stress	REACTOME	R-HSA-2262752
Disease	REACTOME	R-HSA-1643685
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Epstein-Barr virus infection	KEGG	hsa05169

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448785	carbamazepine	Chemical	ClinicalAnnotation	associated		PD	16538175

References

Pubmed ID	Year	Title	Citations
36345598	2023	Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.	1
36345598	2023	Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.	1
36519896	2023	Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA.	1
36519896	2023	Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA.	1
36814356	2023	Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn's Disease.	1
36814356	2023	Downregulation of Heat Shock Protein 72 Contributes to Fibrostenosis in Crohn's Disease.	1
37254218	2023	ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.	2
37254218	2023	ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells.	2
37298493	2023	Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions.	0
37298493	2023	Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions.	0

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Citation

Dessen P

HSPA1A (heat shock protein family A (Hsp70) member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40871/hspa1a-(heat-shock-protein-family-a-(hsp70)-member-1a)