HSPA2 (heat shock protein family A (Hsp70) member 2)

2003-08-01 Affiliation

Identity

HGNC

HSPA2

LOCATION

14q23.3

LOCUSID

3306

ALIAS

HSP70-2,HSP70-3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3306
MIM: 140560
HGNC: 5235
Ensembl: ENSG00000126803

Variants:

dbSNP: 3306
ClinVar: 3306
TCGA: ENSG00000126803
COSMIC: HSPA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126803	ENST00000247207	P54652
ENSG00000126803	ENST00000247207	A0A024R6B5
ENSG00000126803	ENST00000394709	P54652
ENSG00000126803	ENST00000394709	A0A024R6B5

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Antigen processing and presentation	KEGG	ko04612
MAPK signaling pathway	KEGG	hsa04010
Antigen processing and presentation	KEGG	hsa04612
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Spliceosome, Prp19/CDC5L complex	KEGG	hsa_M00353
Spliceosome, 35S U5-snRNP	KEGG	hsa_M00355
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Spliceosome, Prp19/CDC5L complex	KEGG	M00353
Spliceosome, 35S U5-snRNP	KEGG	M00355
Cell Cycle	REACTOME	R-HSA-1640170
Meiosis	REACTOME	R-HSA-1500620
Meiotic synapsis	REACTOME	R-HSA-1221632
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Attenuation phase	REACTOME	R-HSA-3371568
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20975101	2010	Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.	66
17601350	2007	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	27
23209833	2012	The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition.	24
11040178	2000	Genetic factors determine extent of bone loss in inflammatory bowel disease.	21
18813331	2009	Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations.	21
18977241	2008	Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.	20
21373891	2011	Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study.	19
12771604	2003	Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia.	18
17007855	2006	Expression of the HSPA2 gene in ejaculated spermatozoa from adolescents with and without varicocele.	17
17009596	2006	Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.	17

Citation

Dessen P

HSPA2 (heat shock protein family A (Hsp70) member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40874/hspa2-(heat-shock-protein-family-a-(hsp70)-member-2)