HSPB2 (heat shock protein family B (small) member 2)

2003-02-01  

Identity

HGNC
HSPB2
LOCATION
11q23.1
LOCUSID
3316
ALIAS
HSP27,Hs.78846,LOH11CR1K,MKBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3316
MIM: 602179
HGNC: 5247
Ensembl: ENSG00000170276

Variants:

dbSNP: 3316
ClinVar: 3316
TCGA: ENSG00000170276
COSMIC: HSPB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170276ENST00000304298Q16082

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205

References

Pubmed IDYearTitleCitations
125101532003On the role of Hsp27 in regulating apoptosis.96
128971492003HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.96
149630272004Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.65
182993202008Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism.60
128297202003Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation.58
185663452008Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.40
147297282004Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell.36
201012332010Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.36
184407752008Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase.31
192243982009The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock.31

Citation

Dessen P

HSPB2 (heat shock protein family B (small) member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40881/hspb2-(heat-shock-protein-family-b-(small)-member-2)