HSP90AB1 (heat shock protein 90 alpha family class B member 1)

2003-08-01 Affiliation

Identity

HGNC

HSP90AB1

LOCATION

6p21.1

LOCUSID

3326

ALIAS

D6S182,HSP84,HSP90B,HSPC2,HSPCB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3326
MIM: 140572
HGNC: 5258
Ensembl: ENSG00000096384

Variants:

dbSNP: 3326
ClinVar: 3326
TCGA: ENSG00000096384
COSMIC: HSP90AB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000096384	ENST00000353801	P08238
ENSG00000096384	ENST00000353801	A0A024RD80
ENSG00000096384	ENST00000371554	P08238
ENSG00000096384	ENST00000371554	A0A024RD80
ENSG00000096384	ENST00000371646	P08238
ENSG00000096384	ENST00000371646	A0A024RD80
ENSG00000096384	ENST00000620073	P08238
ENSG00000096384	ENST00000620073	A0A024RD80

Expression (GTEx)

500

1000

1500

2000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Progesterone-mediated oocyte maturation	KEGG	ko04914
Prostate cancer	KEGG	ko05215
Antigen processing and presentation	KEGG	hsa04612
Pathways in cancer	KEGG	hsa05200
Prostate cancer	KEGG	hsa05215
Progesterone-mediated oocyte maturation	KEGG	hsa04914
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of diphtheria toxin	REACTOME	R-HSA-5336415
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	REACTOME	R-HSA-168643
Inflammasomes	REACTOME	R-HSA-622312
The NLRP3 inflammasome	REACTOME	R-HSA-844456
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
Regulation of actin dynamics for phagocytic cup formation	REACTOME	R-HSA-2029482
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
Sema3A PAK dependent Axon repulsion	REACTOME	R-HSA-399954
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1 activation	REACTOME	R-HSA-3371511
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Attenuation phase	REACTOME	R-HSA-3371568
The role of GTSE1 in G2/M progression after G2 checkpoint	REACTOME	R-HSA-8852276
Neutrophil degranulation	REACTOME	R-HSA-6798695
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
Aryl hydrocarbon receptor signalling	REACTOME	R-HSA-8937144
IL-17 signaling pathway	KEGG	ko04657
Fluid shear stress and atherosclerosis	KEGG	ko05418
IL-17 signaling pathway	KEGG	hsa04657
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA130232992	bevacizumab	Chemical	ClinicalAnnotation	associated		PD	29871907
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD	29871907

References

Pubmed ID	Year	Title	Citations
38416826	2024	HSP90β controls NLRP3 autoactivation.	0
38416826	2024	HSP90β controls NLRP3 autoactivation.	0
37028636	2023	Despite their structural similarities, the cytosolic isoforms of human Hsp90 show different behaviour in thermal unfolding due to their conformation: An FTIR study.	0
37406487	2023	Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β.	2
37415147	2023	PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.	0
37487085	2023	HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.	1
37729687	2023	Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening.	0
37028636	2023	Despite their structural similarities, the cytosolic isoforms of human Hsp90 show different behaviour in thermal unfolding due to their conformation: An FTIR study.	0
37406487	2023	Proliferation, migration, and resistance to oxidative and thermal stresses of HT1080 cells with knocked out genes encoding Hsp90α and Hsp90β.	2
37415147	2023	PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.	0
37487085	2023	HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.	1
37729687	2023	Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening.	0
35298351	2022	LncRNA RP3-326I13.1 promotes cisplatin resistance in lung adenocarcinoma by binding to HSP90B and upregulating MMP13.	5
35929142	2022	HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma.	6
36114006	2022	ALS-linked loss of Cyclin-F function affects HSP90.	3

Citation

Dessen P

HSP90AB1 (heat shock protein 90 alpha family class B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40887/hsp90ab1-(heat-shock-protein-90-alpha-family-class-b-member-1)