TCEA1 (transcription elongation factor A1)

2004-05-01

Identity

HGNC

TCEA1

LOCATION

8q11.23

LOCUSID

6917

ALIAS

GTF2S,SII,TCEA,TF2S,TFIIS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6917
MIM: 601425
HGNC: 11612
Ensembl: ENSG00000187735

Variants:

dbSNP: 6917
ClinVar: 6917
TCGA: ENSG00000187735
COSMIC: TCEA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187735	ENST00000396401	P23193
ENSG00000187735	ENST00000518310	E5RFI1
ENSG00000187735	ENST00000518784	E5RJ93
ENSG00000187735	ENST00000519704	E5RK46
ENSG00000187735	ENST00000520534	E5RIS7
ENSG00000187735	ENST00000521604	P23193
ENSG00000187735	ENST00000521604	A0A384MTX4
ENSG00000187735	ENST00000522635	B7Z4S1
ENSG00000187735	ENST00000638322	A0A1W2PS15
ENSG00000187735	ENST00000640041	A0A1W2PRL9

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Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
DNA Repair	REACTOME	R-HSA-73894
Dual incision in TC-NER	REACTOME	R-HSA-6782135
Formation of HIV elongation complex in the absence of HIV Tat	REACTOME	R-HSA-167152
Formation of HIV-1 elongation complex containing HIV-1 Tat	REACTOME	R-HSA-167200
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382
Formation of TC-NER Pre-Incision Complex	REACTOME	R-HSA-6781823
Gap-filling DNA repair synthesis and ligation in TC-NER	REACTOME	R-HSA-6782210
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16630816	2006	Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.	54
16630816	2006	Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.	54
16736500	2006	CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.	27
20729154	2010	Transcription factor IIS impacts UV-inhibited transcription.	13
20729154	2010	Transcription factor IIS impacts UV-inhibited transcription.	13
21070792	2011	RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair.	4
21070792	2011	RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair.	4
21596312	2011	RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.	59
21596312	2011	RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.	59
31519522	2019	Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.	56

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Citation

Dessen P

TCEA1 (transcription elongation factor A1)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/409/tcea1-(transcription-elongation-factor-a1)