IBSP (integrin binding sialoprotein)

2003-11-01 Affiliation

Identity

HGNC

IBSP

LOCATION

4q22.1

LOCUSID

3381

ALIAS

BNSP,BSP,BSP-II,SP-II

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3381
MIM: 147563
HGNC: 5341
Ensembl: ENSG00000029559

Variants:

dbSNP: 3381
ClinVar: 3381
TCGA: ENSG00000029559
COSMIC: IBSP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000029559	ENST00000226284	P21815

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Focal adhesion	KEGG	ko04510
ECM-receptor interaction	KEGG	ko04512
Focal adhesion	KEGG	hsa04510
ECM-receptor interaction	KEGG	hsa04512
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Extracellular matrix organization	REACTOME	R-HSA-1474244
ECM proteoglycans	REACTOME	R-HSA-3000178
Integrin cell surface interactions	REACTOME	R-HSA-216083

References

Pubmed ID	Year	Title	Citations
19079262	2009	New sequence variants associated with bone mineral density.	123
12750290	2003	Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells.	62
11968014	2002	Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro.	59
16000302	2005	Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene.	36
20164292	2010	Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women.	34
14524533	2003	Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma.	27
24071501	2014	Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers.	27
19492334	2009	Bone sialoprotein stimulates focal adhesion-related signaling pathways: role in migration and survival of breast and prostate cancer cells.	22
17956871	2007	Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression.	21
19453261	2009	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	20

Citation

Dessen P

IBSP (integrin binding sialoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40908/ibsp-(integrin-binding-sialoprotein)