IGFBP1 (insulin like growth factor binding protein 1)

2003-11-01  

Identity

HGNC
IGFBP1
LOCATION
7p12.3
LOCUSID
3484
ALIAS
AFBP,IBP1,IGF-BP25,PP12,hIGFBP-1

Other Information

Locus ID:

NCBI: 3484
MIM: 146730
HGNC: 5469
Ensembl: ENSG00000146678

Variants:

dbSNP: 3484
ClinVar: 3484
TCGA: ENSG00000146678
COSMIC: IGFBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146678ENST00000275525P08833
ENSG00000146678ENST00000457280C9JXF9
ENSG00000146678ENST00000468955C9J6H2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382469592024Serum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer.1
386275622024Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes.0
387593702024IGFBP1 stabilizes Umod expression through m6A modification to inhibit the occurrence and development of cystitis by blocking NF-κB and ERK signaling pathways.0
382469592024Serum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer.1
386275622024Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes.0
387593702024IGFBP1 stabilizes Umod expression through m6A modification to inhibit the occurrence and development of cystitis by blocking NF-κB and ERK signaling pathways.0
368256842023Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors.2
370833602023A Simple Kit Formulation for Preparation and Exploratory Human Studies of a Novel (99m)Tc-Labeled Fibroblast Activation Protein Inhibitor Tracer for Imaging of the Fibroblast Activation Protein in Cancers.3
371084372023Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability.2
372177312023Associations between IGFBP1 gene polymorphisms and the risk of preeclampsia and fetal growth restriction.1
381743312023Insulin-like growth factor binding protein-1 and insulin in polycystic ovary syndrome: a systematic review and meta-analysis.1
368256842023Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors.2
370833602023A Simple Kit Formulation for Preparation and Exploratory Human Studies of a Novel (99m)Tc-Labeled Fibroblast Activation Protein Inhibitor Tracer for Imaging of the Fibroblast Activation Protein in Cancers.3
371084372023Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability.2
372177312023Associations between IGFBP1 gene polymorphisms and the risk of preeclampsia and fetal growth restriction.1

Citation

Dessen P

IGFBP1 (insulin like growth factor binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40930