IGFBP3 (insulin like growth factor binding protein 3)

2003-02-01  

Identity

HGNC
IGFBP3
LOCATION
7p12.3
LOCUSID
3486
ALIAS
BP-53,IBP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3486
MIM: 146732
HGNC: 5472
Ensembl: ENSG00000146674

Variants:

dbSNP: 3486
ClinVar: 3486
TCGA: ENSG00000146674
COSMIC: IGFBP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146674ENST00000275521P17936
ENSG00000146674ENST00000381083P17936
ENSG00000146674ENST00000381086B3KWK7
ENSG00000146674ENST00000417621H0Y5K2
ENSG00000146674ENST00000428530H0Y485
ENSG00000146674ENST00000448817C9JMX4
ENSG00000146674ENST00000613132A6XND0
ENSG00000146674ENST00000615754A6XND1

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD20860465
PA445742Stomach NeoplasmsDiseaseClinicalAnnotationassociatedPD20860465
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
382240092024Novel therapeutic targets, including IGFBP3, of umbilical cord mesenchymal stem-cell-conditioned medium in intrauterine adhesion.0
384684022024IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome.0
382240092024Novel therapeutic targets, including IGFBP3, of umbilical cord mesenchymal stem-cell-conditioned medium in intrauterine adhesion.0
384684022024IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome.0
366576562023IGFBP3 epigenetic promotion induced by METTL3 boosts cardiac fibroblast activation and fibrosis.4
367667472023Phosphorylation of IGFBP-3 by Casein Kinase 2 Blocks Its Interaction with Hyaluronan, Enabling HA-CD44 Signaling Leading to Increased NSCLC Cell Survival and Cisplatin Resistance.5
368007192023Etiological study of short stature in children and role of insulin like growth factor-1 and insulin like growth factor binding protein-3 as screening markers for growth hormone deficiency.1
368533242023The Association Between the Serum Level of IGF-1 and IGFBP-3 and the Risk of Breast Cancer among Women in the Gaza Strip.1
371889822023MicroRNA-210-3p Regulates Endometriotic Lesion Development by Targeting IGFBP3 in Baboons and Women with Endometriosis.3
372537732023Insulin-like growth factor binding protein-3 induces senescence by inhibiting telomerase activity in MCF-7 breast cancer cells.1
374511392023GATA4 inhibits odontoblastic differentiation of dental pulp stem cells through targeting IGFBP3.0
375113782023Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis.0
376906862023Insulin-like growth factor binding protein-3 mediates hyperosmolar stress-induced mitophagy through the mechanistic target of rapamycin.1
377928672023The relationship between serum leptin, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 levels and clinical parameters in primary fibromyalgia patients.1
379485682023Insulin-like growth factor binding protein 3 promoter variant (rs2854744) is associated with nonalcoholic fatty liver disease.2

Citation

Dessen P

IGFBP3 (insulin like growth factor binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40932/igfbp3-(insulin-like-growth-factor-binding-protein-3)