IL13 (interleukin 13)

2003-11-01  

Identity

HGNC
IL13
LOCATION
5q31.1
LOCUSID
3596
ALIAS
IL-13,P600
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3596
MIM: 147683
HGNC: 5973
Ensembl: ENSG00000169194

Variants:

dbSNP: 3596
ClinVar: 3596
TCGA: ENSG00000169194
COSMIC: IL13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169194ENST00000304506P35225
ENSG00000169194ENST00000617259A0A087WW07

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162372840sunitinibChemicalClinicalAnnotationassociatedPD26387812
PA164712789Hepatitis vaccinesChemicalClinicalAnnotationassociatedPD21111021
PA443624Carcinoma, Renal CellDiseaseClinicalAnnotationassociatedPD26387812

References

Pubmed IDYearTitleCitations
383109742024Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.0
384973432024The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months.0
383109742024Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.0
384973432024The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months.0
359181042023Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling.2
360896282023RNY3 modulates cell proliferation and IL13 mRNA levels in a T lymphocyte model: a possible new epigenetic mechanism of IL-13 regulation.0
362553562023A Pilot Study of Associations Between the Occurrence of Palpitations and Cytokine Gene Variations in Women Prior to Breast Cancer Surgery.0
366393712023Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection.15
367375972023IL-4 and IL-13: Regulators and Effectors of Wound Repair.12
367495692023Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.1
368097152023IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils.0
369249372023The role of interleukin 13 and the type 2 immune pathway in COVID-19: A review.4
372021822023Acute rotavirus infection causes significant activation of the IL-33/IL-13 axis.0
373374112023Interleukin-13 contributes to the occurrence of oral submucosal fibrosis.2
374002902023Cracking the cytokine code in atopic dermatitis reveals IL-13 as dominant driver of disease activity.1

Citation

Dessen P

IL13 (interleukin 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40942/il13-(interleukin-13)