IL17C (interleukin 17C)

2003-06-01  

Identity

HGNC
LOCATION
16q24.2
LOCUSID
ALIAS
CX2,IL-17C

Other Information

Locus ID:

NCBI: 27189
MIM: 604628
HGNC: 5983
Ensembl: ENSG00000124391

Variants:

dbSNP: 27189
ClinVar: 27189
TCGA: ENSG00000124391
COSMIC: IL17C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124391ENST00000244241Q9P0M4

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-17 signalingREACTOMER-HSA-448424
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119845952002Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis.445
219938482011IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.110
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
233595002013Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation.60
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
232210462013IL-17C is a mediator of respiratory epithelial innate immune response.21
238925902014The pattern recognition receptor NOD2 mediates Staphylococcus aureus-induced IL-17C expression in keratinocytes.20
239449332014Toll-like receptor-mediated airway IL-17C enhances epithelial host defense in an autocrine/paracrine manner.20
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
204069642010Risk of meningioma and common variation in genes related to innate immunity.12

Citation

Dessen P

IL17C (interleukin 17C)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40946/il17c-(interleukin-17c)