IL17C (interleukin 17C)

2003-06-01  

Identity

HGNC
IL17C
LOCATION
16q24.2
LOCUSID
27189
ALIAS
CX2,IL-17C

Other Information

Locus ID:

NCBI: 27189
MIM: 604628
HGNC: 5983
Ensembl: ENSG00000124391

Variants:

dbSNP: 27189
ClinVar: 27189
TCGA: ENSG00000124391
COSMIC: IL17C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124391ENST00000244241Q9P0M4

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-17 signalingREACTOMER-HSA-448424
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387043812024IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.0
387043812024IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube.0
372631382023IL-17C neutralization protects the kidney against acute injury and chronic injury.1
372631382023IL-17C neutralization protects the kidney against acute injury and chronic injury.1
354790982022Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.19
361308292022Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.1
354790982022Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19.19
361308292022Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.1
334117482021IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.10
334117482021IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.10
321749262020IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.33
322320152020Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.9
331627882020IL-17C expression and its correlation with pediatric adenoids: a preliminary study.0
321749262020IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.33
322320152020Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells.9

Citation

Dessen P

IL17C (interleukin 17C)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40946/il17c-(interleukin-17c)