IL24 (interleukin 24)

2003-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
C49A,FISP,IL10B,MDA7,MOB5,ST16

Other Information

Locus ID:

NCBI: 11009
MIM: 604136
HGNC: 11346
Ensembl: ENSG00000162892

Variants:

dbSNP: 11009
ClinVar: 11009
TCGA: ENSG00000162892
COSMIC: IL24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162892ENST00000294984Q13007
ENSG00000162892ENST00000367093Q13007
ENSG00000162892ENST00000367095E7ER64
ENSG00000162892ENST00000391929Q13007
ENSG00000162892ENST00000480741E7ETP6
ENSG00000162892ENST00000611909Q13007

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
123516242002Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.75
120552122002The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.66
170833662006Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs.61
169121972006BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis.55
185994612008Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.50
117060202002Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.48
182815152008Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.45
198020072010Cytokine expression and signaling in drug-induced cellular senescence.43
281092882017Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression.43

Citation

Dessen P

IL24 (interleukin 24)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40956/il24-(interleukin-24)