IL4 (interleukin 4)

2003-11-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
BCGF-1,BCGF1,BSF-1,BSF1,IL-4

Other Information

Locus ID:

NCBI: 3565
MIM: 147780
HGNC: 6014
Ensembl: ENSG00000113520

Variants:

dbSNP: 3565
ClinVar: 3565
TCGA: ENSG00000113520
COSMIC: IL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113520ENST00000231449P05112
ENSG00000113520ENST00000231449D4HNR6
ENSG00000113520ENST00000350025P05112
ENSG00000113520ENST00000350025Q5FC01
ENSG00000113520ENST00000622422U3LVN1

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Allograft rejectionKEGGko05330
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Allograft rejectionKEGGhsa05330
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
MeaslesKEGGko05162
MeaslesKEGGhsa05162
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD20921925
PA448497aspirinChemicalClinicalAnnotationassociatedPD20921925

References

Pubmed IDYearTitleCitations
191692542009Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.410
183713772007Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.343
176236482007Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation.158
182431012008Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.158
230874262012IL-4 in the brain: a cytokine to remember.114
156618752005Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo.106
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
271111452016IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
186413142008IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4.75

Citation

Dessen P

IL4 (interleukin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40960/il4-(interleukin-4)