Identity
HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
CD126,HIES5,IL-1Ra,IL-6R,IL-6R-1,IL-6RA,IL6Q,IL6QTL,IL6RA,IL6RQ,gp80
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3570
MIM: 147880
HGNC: 6019
Ensembl: ENSG00000160712
Variants:
dbSNP: 3570
ClinVar: 3570
TCGA: ENSG00000160712
COSMIC: IL6R
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165292659 | tocilizumab | Chemical | ClinicalAnnotation | associated | PD | 24978393, 27958380 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | 24978393, 27958380 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37855360 | 2024 | The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy. | 1 |
| 38116639 | 2024 | Role of interleukin-6 and endothelin-1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid. | 0 |
| 38580710 | 2024 | Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy. | 0 |
| 38791322 | 2024 | No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients. | 0 |
| 37855360 | 2024 | The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy. | 1 |
| 38116639 | 2024 | Role of interleukin-6 and endothelin-1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid. | 0 |
| 38580710 | 2024 | Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy. | 0 |
| 38791322 | 2024 | No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients. | 0 |
| 36066625 | 2023 | A real-world study of interleukin-6 receptor blockade in patients with neuromyelitis optica spectrum disorder. | 2 |
| 36617890 | 2023 | M1-Like Macrophages Modulate Fibrosis and Inflammation of Orbital Fibroblasts in Graves' Orbitopathy: Potential Relevance to Soluble Interleukin-6 Receptor. | 2 |
| 36689568 | 2023 | Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. | 15 |
| 36781081 | 2023 | Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells. | 5 |
| 37052855 | 2023 | The Role of the Soluble Interleukin-6 Receptor in the Progression of Nonalcoholic Fatty Liver Disease. | 3 |
| 37153572 | 2023 | Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis. | 6 |
| 37243282 | 2023 | Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population. | 2 |
Citation
Dessen P
IL6R (interleukin 6 receptor)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40963/il6r-(interleukin-6-receptor)
