Identity
HGNC
LOCATION
12q12
LOCUSID
ALIAS
IMD67,IPD1,IRAK-4,NY-REN-64,REN64
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51135
MIM: 606883
HGNC: 17967
Ensembl: ENSG00000198001
Variants:
dbSNP: 51135
ClinVar: 51135
TCGA: ENSG00000198001
COSMIC: IRAK4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36825363 | 2023 | Pseudomonas Meningitis and Intracranial Hemorrhage in IRAK-4 Deficiency. | 0 |
| 36880831 | 2023 | Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia. | 10 |
| 37172199 | 2023 | Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. | 5 |
| 37744344 | 2023 | Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4. | 0 |
| 37997696 | 2023 | Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension. | 0 |
| 36825363 | 2023 | Pseudomonas Meningitis and Intracranial Hemorrhage in IRAK-4 Deficiency. | 0 |
| 36880831 | 2023 | Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia. | 10 |
| 37172199 | 2023 | Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. | 5 |
| 37744344 | 2023 | Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4. | 0 |
| 37997696 | 2023 | Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension. | 0 |
| 35022428 | 2022 | Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors. | 8 |
| 35271824 | 2022 | IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma. | 14 |
| 35478439 | 2022 | Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children. | 3 |
| 35022428 | 2022 | Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors. | 8 |
| 35271824 | 2022 | IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma. | 14 |
Citation
Dessen P
IRAK4 (interleukin 1 receptor associated kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40989/irak4-(interleukin-1-receptor-associated-kinase-4)
