FCRL4 (Fc receptor like 4)

2003-02-01  

Identity

HGNC
FCRL4
LOCATION
1q23.1
LOCUSID
83417
ALIAS
CD307d,FCRH4,IGFP2,IRTA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83417
MIM: 605876
HGNC: 18507
Ensembl: ENSG00000163518

Variants:

dbSNP: 83417
ClinVar: 83417
TCGA: ENSG00000163518
COSMIC: FCRL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163518ENST00000271532Q96PJ5

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195926452009Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area.146
161576852005Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells.112
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
224912542012Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG.48
241627742013The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.44
219084282011FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.41
128813172003Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT).30
119297512002IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
227163042012IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas.17

Citation

Dessen P

FCRL4 (Fc receptor like 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40995/fcrl4-(fc-receptor-like-4)