ISG20 (interferon stimulated exonuclease gene 20)

2003-11-01  

Identity

HGNC
ISG20
LOCATION
15q26.1
LOCUSID
3669
ALIAS
CD25,HEM45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3669
MIM: 604533
HGNC: 6130
Ensembl: ENSG00000172183

Variants:

dbSNP: 3669
ClinVar: 3669
TCGA: ENSG00000172183
COSMIC: ISG20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172183ENST00000306072Q96AZ6
ENSG00000172183ENST00000379224H3BLY5
ENSG00000172183ENST00000559876H0YMM4
ENSG00000172183ENST00000560741Q96AZ6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

References

Pubmed IDYearTitleCitations
363540072023Internal RNA 2'O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect.7
370587442023Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.0
373409812023Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis.1
373423282023ISG20 stimulates anti-tumor immunity via a double-stranded RNA-induced interferon response in ovarian cancer.0
377315062023Causal relationships between CD25 on immune cells and hip osteoarthritis.3
363540072023Internal RNA 2'O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect.7
370587442023Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.0
373409812023Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis.1
373423282023ISG20 stimulates anti-tumor immunity via a double-stranded RNA-induced interferon response in ovarian cancer.0
377315062023Causal relationships between CD25 on immune cells and hip osteoarthritis.3
361770042022The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individuals.5
361770042022The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individuals.5
331473722021ISG20 and nuclear exosome promote destabilization of nascent transcripts for spliceosomal U snRNAs and U1 variants.5
338304342021Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation.10
338968362021High expression of ISG20 predicts a poor prognosis in acute myeloid leukemia.1

Citation

Dessen P

ISG20 (interferon stimulated exonuclease gene 20)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40997/isg20-(interferon-stimulated-exonuclease-gene-20)