ITGA2 (integrin subunit alpha 2)

2003-08-01 Affiliation

Identity

HGNC

ITGA2

LOCATION

5q11.2

LOCUSID

3673

ALIAS

BR,CD49B,GPIa,HPA-5,VLA-2,VLAA2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3673
MIM: 192974
HGNC: 6137
Ensembl: ENSG00000164171

Variants:

dbSNP: 3673
ClinVar: 3673
TCGA: ENSG00000164171
COSMIC: ITGA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000164171	ENST00000296585	P17301
ENSG00000164171	ENST00000503810	D6RG08
ENSG00000164171	ENST00000509814	E7EMF1
ENSG00000164171	ENST00000509960	E9PB77
ENSG00000164171	ENST00000510722	E7ESP4
ENSG00000164171	ENST00000513685	D6R9H3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Focal adhesion	KEGG	ko04510
ECM-receptor interaction	KEGG	ko04512
Hematopoietic cell lineage	KEGG	ko04640
Regulation of actin cytoskeleton	KEGG	ko04810
Small cell lung cancer	KEGG	ko05222
Focal adhesion	KEGG	hsa04510
ECM-receptor interaction	KEGG	hsa04512
Hematopoietic cell lineage	KEGG	hsa04640
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Small cell lung cancer	KEGG	hsa05222
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	ko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	hsa05412
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Platelet activation	KEGG	hsa04611
Hemostasis	REACTOME	R-HSA-109582
Platelet Adhesion to exposed collagen	REACTOME	R-HSA-75892
Signal Transduction	REACTOME	R-HSA-162582
Extracellular matrix organization	REACTOME	R-HSA-1474244
Laminin interactions	REACTOME	R-HSA-3000157
Non-integrin membrane-ECM interactions	REACTOME	R-HSA-3000171
Syndecan interactions	REACTOME	R-HSA-3000170
ECM proteoglycans	REACTOME	R-HSA-3000178
Integrin cell surface interactions	REACTOME	R-HSA-216083
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
L1CAM interactions	REACTOME	R-HSA-373760
CHL1 interactions	REACTOME	R-HSA-447041
Signaling by MET	REACTOME	R-HSA-6806834
MET promotes cell motility	REACTOME	R-HSA-8875878
MET activates PTK2 signaling	REACTOME	R-HSA-8874081

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA26716	COL3A1	Gene	Pathway	associated		20938371
PA26717	COL4A1	Gene	Pathway	associated		20938371
PA26718	COL4A2	Gene	Pathway	associated		20938371
PA33384	PLCB1	Gene	Pathway	associated		20938371
PA33393	PLCG2	Gene	Pathway	associated		20938371
PA35041	COL1A1	Gene	Pathway	associated		20938371
PA35042	COL1A2	Gene	Pathway	associated		20938371
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	15205592, 16214444, 16493486, 17157856, 22940005
PA443797	Coronary Disease	Disease	ClinicalAnnotation	associated	PD	15205592, 16214444, 16493486, 17157856, 22940005
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PD	15205592, 16214444, 16493486, 17157856, 22940005
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	15205592, 16214444, 16493486, 17157856, 22940005
PA449053	clopidogrel	Chemical	ClinicalAnnotation	associated	PD	15205592, 16214444, 16493486, 17157856, 22940005

References

Pubmed ID	Year	Title	Citations
37804164	2024	Integrin α2 promotes immune escape in non-small-cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8 + T-cell activity.	0
38142122	2024	ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation.	0
37804164	2024	Integrin α2 promotes immune escape in non-small-cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8 + T-cell activity.	0
38142122	2024	ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation.	0
36151049	2023	Integrin alpha 2 is associated with tumor progression and postoperative recurrence in non-small cell lung cancer.	2
36420922	2023	Hypomethylation-mediated overexpression of ITGA2 stimulates cell invasion and migration of thyroid carcinoma.	0
36766725	2023	Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells.	0
37311571	2023	BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.	0
37881431	2023	High expression ITGA2 affects the expression of MET, PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients.	0
37907515	2023	SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.	2
36151049	2023	Integrin alpha 2 is associated with tumor progression and postoperative recurrence in non-small cell lung cancer.	2
36420922	2023	Hypomethylation-mediated overexpression of ITGA2 stimulates cell invasion and migration of thyroid carcinoma.	0
36766725	2023	Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells.	0
37311571	2023	BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.	0
37881431	2023	High expression ITGA2 affects the expression of MET, PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients.	0

Citation

Dessen P

ITGA2 (integrin subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41002/itga2-(integrin-subunit-alpha-2)