Identity
HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
BDPLT16,BDPLT2,CD41,CD41B,GP2B,GPIIb,GT,GT1,GTA,HPA3,PPP1R93
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3674
MIM: 607759
HGNC: 6138
Ensembl: ENSG00000005961
Variants:
dbSNP: 3674
ClinVar: 3674
TCGA: ENSG00000005961
COSMIC: ITGA2B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000005961 | ENST00000262407 | P08514 |
| ENSG00000005961 | ENST00000587295 | K7EP83 |
| ENSG00000005961 | ENST00000648408 | A0A3B3IU79 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33384 | PLCB1 | Gene | Pathway | associated | 20938371 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20938371 | ||
| PA448006 | abciximab | Chemical | Pathway | associated | 20938371 | ||
| PA449483 | eptifibatide | Chemical | Pathway | associated | 20938371 | ||
| PA451698 | tirofiban | Chemical | Pathway | associated | 20938371 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38951065 | 2024 | [Pedigree Analysis and Molecular Mechanism Study of Hereditary Glanzmann Thrombasthenia Caused by Compound Heterozygous Mutation of the ITGA2B Gene]. | 0 |
| 38951065 | 2024 | [Pedigree Analysis and Molecular Mechanism Study of Hereditary Glanzmann Thrombasthenia Caused by Compound Heterozygous Mutation of the ITGA2B Gene]. | 0 |
| 37210732 | 2023 | Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β-propeller mutations reported in Indian Glanzmann thrombasthenia patients. | 0 |
| 37210732 | 2023 | Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β-propeller mutations reported in Indian Glanzmann thrombasthenia patients. | 0 |
| 34275420 | 2022 | New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains. | 1 |
| 35054807 | 2022 | Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A. | 3 |
| 36591264 | 2022 | Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. | 4 |
| 34275420 | 2022 | New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains. | 1 |
| 35054807 | 2022 | Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A. | 3 |
| 36591264 | 2022 | Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. | 4 |
| 32089034 | 2021 | Identification of three novel pathogenic ITGA2B and one novel pathogenic ITGB3 mutations in patients with hereditary Glanzmann's thrombasthenia living in Eastern Turkey. | 1 |
| 33267658 | 2021 | Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation. | 12 |
| 33928629 | 2021 | Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice. | 2 |
| 34007003 | 2021 | ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis. | 23 |
| 34066320 | 2021 | Genetic Confirmation and Identification of Novel Variants for Glanzmann Thrombasthenia and Other Inherited Platelet Function Disorders: A Study by the Korean Pediatric Hematology Oncology Group (KPHOG). | 0 |
Citation
Dessen P
ITGA2B (integrin subunit alpha 2b)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41003/itga2b-(integrin-subunit-alpha-2b)
