ITGAE (integrin subunit alpha E)

2003-11-01 Affiliation

Identity

HGNC

ITGAE

LOCATION

17p13.2

LOCUSID

3682

ALIAS

CD103,HUMINAE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3682
MIM: 604682
HGNC: 6147
Ensembl: ENSG00000083457

Variants:

dbSNP: 3682
ClinVar: 3682
TCGA: ENSG00000083457
COSMIC: ITGAE

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000083457	ENST00000263087	P38570
ENSG00000083457	ENST00000574026	K7EQU0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Regulation of actin cytoskeleton	KEGG	ko04810
Regulation of actin cytoskeleton	KEGG	hsa04810
Extracellular matrix organization	REACTOME	R-HSA-1474244
Integrin cell surface interactions	REACTOME	R-HSA-216083

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38561495	2024	Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.	0
38781659	2024	Cryo-EM structure of I domain-containing integrin αEβ7.	0
38561495	2024	Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.	0
38781659	2024	Cryo-EM structure of I domain-containing integrin αEβ7.	0
35776160	2023	The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer.	9
36792124	2023	CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.	10
35776160	2023	The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer.	9
36792124	2023	CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.	10
34658046	2022	CD103 integrin identifies a high IL-10-producing FoxP3(+) regulatory T-cell population suppressing allergic airway inflammation.	4
36036450	2022	The multifunctional nature of CD103 (αEβ7 integrin) signaling in tissue-resident lymphocytes.	4
34658046	2022	CD103 integrin identifies a high IL-10-producing FoxP3(+) regulatory T-cell population suppressing allergic airway inflammation.	4
36036450	2022	The multifunctional nature of CD103 (αEβ7 integrin) signaling in tissue-resident lymphocytes.	4
33479027	2021	CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma.	12
33827905	2021	Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.	57
34298400	2021	The differentiation of new human CD303(+) Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells.	1

Citation

Dessen P

ITGAE (integrin subunit alpha E)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41012/itgae-(integrin-subunit-alpha-e)