Identity
HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
CD11B,CR3A,MAC-1,MAC1A,MO1A,SLEB6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3684
MIM: 120980
HGNC: 6149
Ensembl: ENSG00000169896
Variants:
dbSNP: 3684
ClinVar: 3684
TCGA: ENSG00000169896
COSMIC: ITGAM
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169896 | ENST00000544665 | P11215 |
| ENSG00000169896 | ENST00000565142 | I3NI33 |
| ENSG00000169896 | ENST00000567031 | H3BMV4 |
| ENSG00000169896 | ENST00000648685 | P11215 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36822392 | 2024 | CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization. | 4 |
| 37562584 | 2024 | Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes. | 0 |
| 37937521 | 2024 | Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study. | 0 |
| 38413872 | 2024 | ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis. | 0 |
| 38637126 | 2024 | ITGAM is a critical gene in ischemic stroke. | 0 |
| 38907234 | 2024 | Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression. | 0 |
| 36822392 | 2024 | CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization. | 4 |
| 37562584 | 2024 | Immune Inhibitory Molecule PD-1 Homolog (VISTA) Colocalizes with CD11b Myeloid Cells in Melanoma and Is Associated with Poor Outcomes. | 0 |
| 37937521 | 2024 | Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study. | 0 |
| 38413872 | 2024 | ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis. | 0 |
| 38637126 | 2024 | ITGAM is a critical gene in ischemic stroke. | 0 |
| 38907234 | 2024 | Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression. | 0 |
| 36796515 | 2023 | The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation. | 2 |
| 37236195 | 2023 | Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity. | 13 |
| 37239465 | 2023 | ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity. | 0 |
Citation
Dessen P
ITGAM (integrin subunit alpha M)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41014/itgam-(integrin-subunit-alpha-m)
