ITGB4 (integrin subunit beta 4)

2003-02-01  

Identity

HGNC
ITGB4
LOCATION
17q25.1
LOCUSID
3691
ALIAS
CD104,GP150
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3691
MIM: 147557
HGNC: 6158
Ensembl: ENSG00000132470

Variants:

dbSNP: 3691
ClinVar: 3691
TCGA: ENSG00000132470
COSMIC: ITGB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132470ENST00000200181P16144
ENSG00000132470ENST00000200181A0A024R8T0
ENSG00000132470ENST00000449880P16144
ENSG00000132470ENST00000450894P16144
ENSG00000132470ENST00000450894A0A024R8K7
ENSG00000132470ENST00000578318J3KSH9
ENSG00000132470ENST00000579662P16144
ENSG00000132470ENST00000579662A0A024R8K7
ENSG00000132470ENST00000582629J3QQL2
ENSG00000132470ENST00000584939J3QRK0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Type I hemidesmosome assemblyREACTOMER-HSA-446107
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Syndecan interactionsREACTOMER-HSA-3000170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371605552024Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4.4
380718872024Unraveling dedifferentiation and metastasis traces in pancreatic ductal adenocarcinoma ductal cells: Insights from single-cell RNA sequencing analysis of ITGB4 and C19orf33.1
381312292024Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD).0
381725032024ITGB4 upregulation is associated with progression of lower grade glioma.0
382816172024ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.0
383758212024MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway.1
388313352024NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.0
371605552024Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4.4
380718872024Unraveling dedifferentiation and metastasis traces in pancreatic ductal adenocarcinoma ductal cells: Insights from single-cell RNA sequencing analysis of ITGB4 and C19orf33.1
381312292024Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD).0
381725032024ITGB4 upregulation is associated with progression of lower grade glioma.0
382816172024ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.0
383758212024MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway.1
388313352024NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.0
351123142023Revising the Role of Integrin Subunit β4 Expression in Colon Cancer Progression and Survival.0

Citation

Dessen P

ITGB4 (integrin subunit beta 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41020/itgb4-(integrin-subunit-beta-4)