ITGB8 (integrin subunit beta 8)

2003-08-01  

Identity

HGNC
LOCATION
7p21.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3696
MIM: 604160
HGNC: 6163
Ensembl: ENSG00000105855

Variants:

dbSNP: 3696
ClinVar: 3696
TCGA: ENSG00000105855
COSMIC: ITGB8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105855ENST00000222573P26012
ENSG00000105855ENST00000537992P26012

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Cell adhesion molecules (CAMs)KEGGko04514
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Cell adhesion molecules (CAMs)KEGGhsa04514
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209569442011MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8.134
199201742009Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.96
216467182011Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.67
167022132006Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
269011522016Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.59
218598292011Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin.47
243672602013αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.42
222792052012Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β.33
128759732003Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.27

Citation

Dessen P

ITGB8 (integrin subunit beta 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41024/itgb8-(integrin-subunit-beta-8)