Identity
HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
ABRI,BRI,BRI2,BRICD2B,E25B,E3-16,FBD,RDGCA,imBRI2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9445
MIM: 603904
HGNC: 6174
Ensembl: ENSG00000136156
Variants:
dbSNP: 9445
ClinVar: 9445
TCGA: ENSG00000136156
COSMIC: ITM2B
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Amyloid fiber formation | REACTOME | R-HSA-977225 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37792719 | 2024 | Exosomal miRNA-166-5p derived from G-MDSCs promotes proliferation by targeting ITM3E in colorectal cancer. | 0 |
| 38289121 | 2024 | MicroRNA-196a-5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma. | 1 |
| 37792719 | 2024 | Exosomal miRNA-166-5p derived from G-MDSCs promotes proliferation by targeting ITM3E in colorectal cancer. | 0 |
| 38289121 | 2024 | MicroRNA-196a-5p facilitates the onset and progression via targeting ITM2B in esophageal squamous cell carcinoma. | 1 |
| 36935047 | 2023 | Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain. | 2 |
| 37038821 | 2023 | A Novel c.800G>C Variant of the ITM2B Gene in Familial Korean Dementia. | 3 |
| 37220701 | 2023 | Identification of glycolytic proteins as binding partners of Bri2 BRICHOS domain. | 0 |
| 36935047 | 2023 | Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain. | 2 |
| 37038821 | 2023 | A Novel c.800G>C Variant of the ITM2B Gene in Familial Korean Dementia. | 3 |
| 37220701 | 2023 | Identification of glycolytic proteins as binding partners of Bri2 BRICHOS domain. | 0 |
| 32826790 | 2021 | DEEP PHENOTYPING AND FURTHER INSIGHTS INTO ITM2B-RELATED RETINAL DYSTROPHY. | 2 |
| 33172889 | 2021 | Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission. | 10 |
| 33690096 | 2021 | The synthesis and characterization of Bri2 BRICHOS coated magnetic particles and their application to protein fishing: Identification of novel binding proteins. | 0 |
| 33814452 | 2021 | A Novel ITM2B Mutation Associated with Familial Chinese Dementia. | 8 |
| 34298087 | 2021 | Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan. | 1 |
Citation
Dessen P
ITM2B (integral membrane protein 2B)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41025
