ITPKB (inositol-trisphosphate 3-kinase B)

2003-05-01  

Identity

HGNC
ITPKB
LOCATION
1q42.12
LOCUSID
3707
ALIAS
IP3-3KB,IP3K,IP3K-B,IP3KB,PIG37
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3707
MIM: 147522
HGNC: 6179
Ensembl: ENSG00000143772

Variants:

dbSNP: 3707
ClinVar: 3707
TCGA: ENSG00000143772
COSMIC: ITPKB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143772ENST00000272117P27987
ENSG00000143772ENST00000366784P27987
ENSG00000143772ENST00000429204P27987

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Calcium signaling pathwayKEGGko04020
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Calcium signaling pathwayKEGGhsa04020
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP3 and IP4 in the cytosolREACTOMER-HSA-1855204

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
384383462024Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis.1
384383462024Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis.1
367683212023Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.1
371081692023Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk.2
367683212023Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.1
371081692023Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk.2
342440372022Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.1
342440372022Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.1
319878462020Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency.3
319878462020Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency.3
310818032019Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.16
310818032019Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.16
298718742018Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.4
298718742018Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.4
274851222016miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.73

Citation

Dessen P

ITPKB (inositol-trisphosphate 3-kinase B)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41026/itpkb-(inositol-trisphosphate-3-kinase-b)