JTB (jumping translocation breakpoint)

2003-02-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
HJTB,HSPC222,PAR,hJT
FUSION GENES

Other Information

Locus ID:

NCBI: 10899
MIM: 604671
HGNC: 6201
Ensembl: ENSG00000143543

Variants:

dbSNP: 10899
ClinVar: 10899
TCGA: ENSG00000143543
COSMIC: JTB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143543ENST00000271843O76095
ENSG00000143543ENST00000356648O76095
ENSG00000143543ENST00000368589O76095
ENSG00000143543ENST00000428469O76095

Expression (GTEx)

0
50
100
150
200
250
300
350

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125862952003Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.24
226158442012HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression.6
194870722009Interacting with HBsAg compromises resistance of jumping translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells.4
212252292011PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.0
220790492012The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.0
232974972012[Downregulation of PAR expression induces the apoptosis of human prostate cancer PC3 cells and increases the Bcl-2/Bax ratio].0

Citation

Dessen P

JTB (jumping translocation breakpoint)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41044/jtb-(jumping-translocation-breakpoint)