Identity
HGNC
LOCATION
3p25.2
LOCUSID
ALIAS
ARF-GEP100,ARFGEP100,BRAG2,GEP100,IDDSSBA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9922
MIM: 610166
HGNC: 29112
Ensembl: ENSG00000144711
Variants:
dbSNP: 9922
ClinVar: 9922
TCGA: ENSG00000144711
COSMIC: IQSEC1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Endocytosis | KEGG | ko04144 |
| Endocytosis | KEGG | hsa04144 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37495273 | 2023 | Contribution of gene polymorphisms on 3p25 to salivary gland carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese Han population. | 0 |
| 37495273 | 2023 | Contribution of gene polymorphisms on 3p25 to salivary gland carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese Han population. | 0 |
| 36517907 | 2022 | circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway. | 3 |
| 36517907 | 2022 | circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway. | 3 |
| 33712589 | 2021 | An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. | 11 |
| 33712589 | 2021 | An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. | 11 |
| 32234213 | 2020 | Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. | 30 |
| 32234213 | 2020 | Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. | 30 |
| 31607425 | 2019 | Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. | 17 |
| 31607425 | 2019 | Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. | 17 |
| 26884337 | 2016 | Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. | 18 |
| 26884337 | 2016 | Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. | 18 |
| 24522833 | 2014 | Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. | 12 |
| 24902879 | 2014 | Epidermal growth factor receptor-GEP100-Arf6 axis affects the prognosis of lung adenocarcinoma. | 14 |
| 24522833 | 2014 | Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. | 12 |
Citation
Dessen P
IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41061/iqsec1-(iq-motif-and-sec7-domain-arfgef-1)
