IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)

2003-05-01  

Identity

HGNC
LOCATION
3p25.2
LOCUSID
ALIAS
ARF-GEP100,ARFGEP100,BRAG2,GEP100,IDDSSBA
FUSION GENES

Other Information

Locus ID:

NCBI: 9922
MIM: 610166
HGNC: 29112
Ensembl: ENSG00000144711

Variants:

dbSNP: 9922
ClinVar: 9922
TCGA: ENSG00000144711
COSMIC: IQSEC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144711ENST00000273221Q6DN90
ENSG00000144711ENST00000613206A0A087WWK8
ENSG00000144711ENST00000618604A0A0C4DGT3
ENSG00000144711ENST00000646269A0A2R8Y7T6
ENSG00000144711ENST00000647458A0A2R8Y695
ENSG00000144711ENST00000648114A0A3B3IRZ4
ENSG00000144711ENST00000648386A0A3B3IU98

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180842812008GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.97
164612862006The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.61
168072912006GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin.36
217957012011Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.26
206137662010Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms.22
218580862011GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.22
228154872012BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).22
219664912011Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.19
226137142012The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site.16
227017122012GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells.13

Citation

Dessen P

IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41061/iqsec1-(iq-motif-and-sec7-domain-arfgef-1)