KIF2C (kinesin family member 2C)

2003-08-01  

Identity

HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
CT139,KNSL6,MCAK
FUSION GENES

Other Information

Locus ID:

NCBI: 11004
MIM: 604538
HGNC: 6393
Ensembl: ENSG00000142945

Variants:

dbSNP: 11004
ClinVar: 11004
TCGA: ENSG00000142945
COSMIC: KIF2C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142945ENST00000372217Q99661
ENSG00000142945ENST00000372224Q99661
ENSG00000142945ENST00000372224A0A140VKF1
ENSG00000142945ENST00000423289H0Y5Z9
ENSG00000142945ENST00000452259Q5JR91
ENSG00000142945ENST00000455186Q5JR89

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

References

Pubmed IDYearTitleCitations
384931502024Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.0
384931502024Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.0
364485882023Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.1
378631232023KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.1
364485882023Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.1
378631232023KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.1
351019222022Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.4
356225002022KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.5
357203232022Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.5
360297262022Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.0
351019222022Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.4
356225002022KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.5
357203232022Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.5
360297262022Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.0
327483492021KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.56

Citation

Dessen P

KIF2C (kinesin family member 2C)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41069/kif2c-(kinesin-family-member-2c)