KLK2 (kallikrein related peptidase 2)

2003-02-01  

Identity

HGNC
KLK2
LOCATION
19q13.33
LOCUSID
3817
ALIAS
KLK2A2,hGK-1,hK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3817
MIM: 147960
HGNC: 6363
Ensembl: ENSG00000167751

Variants:

dbSNP: 3817
ClinVar: 3817
TCGA: ENSG00000167751
COSMIC: KLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167751ENST00000325321P20151
ENSG00000167751ENST00000325321A0A024R4J4
ENSG00000167751ENST00000358049P20151
ENSG00000167751ENST00000358049A0A024R4N3
ENSG00000167751ENST00000391810P20151
ENSG00000167751ENST00000593493M0R2W5
ENSG00000167751ENST00000594174M0R1T3
ENSG00000167751ENST00000595050A0A075B7A6
ENSG00000167751ENST00000595316Q6T774
ENSG00000167751ENST00000597439P20151
ENSG00000167751ENST00000597727Q6T774
ENSG00000167751ENST00000597911M0R0M2
ENSG00000167751ENST00000599121Q6T774
ENSG00000167751ENST00000599568M0R0M4
ENSG00000167751ENST00000600690M0QXQ7

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383968982024Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2.0
383968982024Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2.0
344869982021Early prediction of prostate cancer biochemical recurrence and identification of disease persistence using PSA isoforms and human kallikrein-2.1
344869982021Early prediction of prostate cancer biochemical recurrence and identification of disease persistence using PSA isoforms and human kallikrein-2.1
326283002020Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer.9
326283002020Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer.9
310436812019Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer.2
310436812019Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer.2
265822032016A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.9
265822032016A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.9
258472862015Trp(250) -hK2 is defective in intracellular trafficking and activates the unfolded protein response.0
258472862015Trp(250) -hK2 is defective in intracellular trafficking and activates the unfolded protein response.0
241222032014Human kallikrein 2 (KLK2) promotes prostate cancer cell growth via function as a modulator to promote the ARA70-enhanced androgen receptor transactivation.23
242707972014Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.14
247112542014Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia.14

Citation

Dessen P

KLK2 (kallikrein related peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41082/klk2-(kallikrein-related-peptidase-2)