KLK2 (kallikrein related peptidase 2)

2003-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
KLK2A2,hGK-1,hK2
FUSION GENES

Other Information

Locus ID:

NCBI: 3817
MIM: 147960
HGNC: 6363
Ensembl: ENSG00000167751

Variants:

dbSNP: 3817
ClinVar: 3817
TCGA: ENSG00000167751
COSMIC: KLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167751ENST00000325321P20151
ENSG00000167751ENST00000325321A0A024R4J4
ENSG00000167751ENST00000358049P20151
ENSG00000167751ENST00000358049A0A024R4N3
ENSG00000167751ENST00000391810P20151
ENSG00000167751ENST00000593493M0R2W5
ENSG00000167751ENST00000594174M0R1T3
ENSG00000167751ENST00000595050A0A075B7A6
ENSG00000167751ENST00000595316Q6T774
ENSG00000167751ENST00000597439P20151
ENSG00000167751ENST00000597727Q6T774
ENSG00000167751ENST00000597911M0R0M2
ENSG00000167751ENST00000599121Q6T774
ENSG00000167751ENST00000599568M0R0M4
ENSG00000167751ENST00000600690M0QXQ7

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
193184322009Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.60
210715402011Validation of genome-wide prostate cancer associations in men of African descent.51
199024742010Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans.39
184511332008Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer.31
204604802010Susceptibility loci associated with prostate cancer progression and mortality.30
204241352010Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.29
204241352010Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.29
193721412009Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.24
236834752013Predictive value of four kallikrein markers for pathologically insignificant compared with aggressive prostate cancer in radical prostatectomy specimens: results from the European Randomized Study of Screening for Prostate Cancer section Rotterdam.24

Citation

Dessen P

KLK2 (kallikrein related peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41082/klk2-(kallikrein-related-peptidase-2)