KLK3 (kallikrein related peptidase 3)

2003-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
APS,KLK2A1,PSA,hK3
FUSION GENES

Other Information

Locus ID:

NCBI: 354
MIM: 176820
HGNC: 6364
Ensembl: ENSG00000142515

Variants:

dbSNP: 354
ClinVar: 354
TCGA: ENSG00000142515
COSMIC: KLK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142515ENST00000326003P07288
ENSG00000142515ENST00000326003Q546G3
ENSG00000142515ENST00000360617P07288
ENSG00000142515ENST00000422986A0A0B4J1X3
ENSG00000142515ENST00000593997P07288
ENSG00000142515ENST00000595392M0QX57
ENSG00000142515ENST00000595952P07288
ENSG00000142515ENST00000596185Q8WTQ8
ENSG00000142515ENST00000597286M0QZF9
ENSG00000142515ENST00000597483M0R294
ENSG00000142515ENST00000598145M0R1F0
ENSG00000142515ENST00000601503M0R1Z7
ENSG00000142515ENST00000617027Q8NCW4

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500

Pathways

PathwaySourceExternal ID
Prostate cancerKEGGko05215
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182640972008Multiple newly identified loci associated with prostate cancer susceptibility.417
212124122011miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation.104
227050542012Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer.104
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
195421902009Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro.83
126263902003Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins.80
211600772010Genetic correction of PSA values using sequence variants associated with PSA levels.69
125890222003Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex.60
193184322009Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.60
223254472012Three-Tesla magnetic resonance-guided prostate biopsy in men with increased prostate-specific antigen and repeated, negative, random, systematic, transrectal ultrasound biopsies: detection of clinically significant prostate cancers.57

Citation

Dessen P

KLK3 (kallikrein related peptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41083/klk3-(kallikrein-related-peptidase-3)