KLK3 (kallikrein related peptidase 3)

2003-02-01  

Identity

HGNC
KLK3
LOCATION
19q13.33
LOCUSID
354
ALIAS
APS,KLK2A1,PSA,hK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 354
MIM: 176820
HGNC: 6364
Ensembl: ENSG00000142515

Variants:

dbSNP: 354
ClinVar: 354
TCGA: ENSG00000142515
COSMIC: KLK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142515ENST00000326003P07288
ENSG00000142515ENST00000326003Q546G3
ENSG00000142515ENST00000360617P07288
ENSG00000142515ENST00000422986A0A0B4J1X3
ENSG00000142515ENST00000593997P07288
ENSG00000142515ENST00000595392M0QX57
ENSG00000142515ENST00000595952P07288
ENSG00000142515ENST00000596185Q8WTQ8
ENSG00000142515ENST00000597286M0QZF9
ENSG00000142515ENST00000597483M0R294
ENSG00000142515ENST00000598145M0R1F0
ENSG00000142515ENST00000601503M0R1Z7
ENSG00000142515ENST00000617027Q8NCW4

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Prostate cancerKEGGko05215
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381111342024Prostate-specific antigen: An unfamiliar protein in the human salivary glands.1
381111342024Prostate-specific antigen: An unfamiliar protein in the human salivary glands.1
367085712023Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.2
367573722023[Immuno-analytical characteristics of PSA and derived biomarkers (total PSA, free PSA, p2PSA)].0
368576382023Prostate-Specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death.10
369959902023The effect of encomir-93 mimic transfection on the expression of miR-93 and PSA and androgen receptor in prostate cancer LNcap cell line.0
375923242023Association of Kallikrein Related Peptidase 3 (KLK3) gene with dermatophytosis in the UK biobank cohort.1
377133212023Ki67 and prostate specific antigen are prognostic in metastatic hormone naïve prostate cancer.0
378065322023RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer.1
367085712023Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.2
367573722023[Immuno-analytical characteristics of PSA and derived biomarkers (total PSA, free PSA, p2PSA)].0
368576382023Prostate-Specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death.10
369959902023The effect of encomir-93 mimic transfection on the expression of miR-93 and PSA and androgen receptor in prostate cancer LNcap cell line.0
375923242023Association of Kallikrein Related Peptidase 3 (KLK3) gene with dermatophytosis in the UK biobank cohort.1
377133212023Ki67 and prostate specific antigen are prognostic in metastatic hormone naïve prostate cancer.0

Citation

Dessen P

KLK3 (kallikrein related peptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41083/klk3-(kallikrein-related-peptidase-3)