Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3821
MIM: 161555
HGNC: 6374
Ensembl: ENSG00000134545
Variants:
dbSNP: 3821
ClinVar: 3821
TCGA: ENSG00000134545
COSMIC: KLRC1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 | |
| PA165107055 | certolizumab pegol | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 | |
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 | |
| PA449515 | etanercept | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 | |
| PA452347 | glucocorticoids | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 | |
| PA452639 | infliximab | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 26453102 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36897779 | 2023 | KIR(+)CD8(+) and NKG2A(+)CD8(+) T cells are distinct innate-like populations in humans. | 3 |
| 36931723 | 2023 | NKG2A and circulating extracellular vesicles are key regulators of natural killer cell activity in prostate cancer after prostatectomy. | 0 |
| 37352688 | 2023 | Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder. | 1 |
| 37386090 | 2023 | The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells. | 7 |
| 37653112 | 2023 | Association of inhibitory NKG2A and activating NKG2D natural killer cell receptor genes with resistance to SARS-CoV-2 infection in a western Indian population. | 0 |
| 37675109 | 2023 | KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. | 1 |
| 37901227 | 2023 | Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells. | 0 |
| 38064568 | 2023 | Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis. | 4 |
| 36897779 | 2023 | KIR(+)CD8(+) and NKG2A(+)CD8(+) T cells are distinct innate-like populations in humans. | 3 |
| 36931723 | 2023 | NKG2A and circulating extracellular vesicles are key regulators of natural killer cell activity in prostate cancer after prostatectomy. | 0 |
| 37352688 | 2023 | Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder. | 1 |
| 37386090 | 2023 | The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells. | 7 |
| 37653112 | 2023 | Association of inhibitory NKG2A and activating NKG2D natural killer cell receptor genes with resistance to SARS-CoV-2 infection in a western Indian population. | 0 |
| 37675109 | 2023 | KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. | 1 |
| 37901227 | 2023 | Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells. | 0 |
Citation
Dessen P
KLRC1 (killer cell lectin like receptor C1)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41090/klrc1-(killer-cell-lectin-like-receptor-c1)
