KLRC2 (killer cell lectin like receptor C2)

2003-06-01 Affiliation

Identity

HGNC

KLRC2

LOCATION

12p13.2

LOCUSID

3822

ALIAS

CD159c,NKG2-C,NKG2C

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3822
MIM: 602891
HGNC: 6375
Ensembl: ENSG00000205809

Variants:

dbSNP: 3822
ClinVar: 3822
TCGA: ENSG00000205809
COSMIC: KLRC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000205809	ENST00000381901	J3KPJ4
ENSG00000205809	ENST00000381902	P26717
ENSG00000205809	ENST00000535069	H0YFK4
ENSG00000205809	ENST00000536833	F5H518
ENSG00000205809	ENST00000537017	H0YGY2
ENSG00000205809	ENST00000619500	A0A087WV37

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Antigen processing and presentation	KEGG	hsa04612
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491

References

Pubmed ID	Year	Title	Citations
24740502	2014	Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.	70
27117418	2016	Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.	63
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
23637420	2013	Human cytomegalovirus-induced NKG2C(hi) CD57(hi) natural killer cells are effectors dependent on humoral antiviral immunity.	46
25150297	2014	Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions.	37
24030638	2013	NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.	32
25667418	2015	Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus.	28
22074011	2012	NKG2C deletion is a risk factor of HIV infection.	27
22965785	2012	Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children.	26
23396942	2013	Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis.	26

Citation

Dessen P

KLRC2 (killer cell lectin like receptor C2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41091/klrc2-(killer-cell-lectin-like-receptor-c2)