KPNA3 (karyopherin subunit alpha 3)

2003-05-01  

Identity

HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
IPOA4,SRP1,SRP1gamma,SRP4,hSRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 3839
MIM: 601892
HGNC: 6396
Ensembl: ENSG00000102753

Variants:

dbSNP: 3839
ClinVar: 3839
TCGA: ENSG00000102753
COSMIC: KPNA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102753ENST00000261667O00505
ENSG00000102753ENST00000261667A0A024RDV7
ENSG00000102753ENST00000436760H0Y4S9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
NS1 Mediated Effects on Host PathwaysREACTOMER-HSA-168276
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
300985952018LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3.23
281795302017Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.19
262458962015Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.8
294760132018Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.8
229603382012KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence.6
166441222006A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.5
166441222006A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.5
158829132005The KPNA3 gene may be a susceptibility candidate for schizophrenia.1

Citation

Dessen P

KPNA3 (karyopherin subunit alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41098/kpna3-(karyopherin-subunit-alpha-3)