IPO5 (importin 5)

2003-05-01  

Identity

HGNC
IPO5
LOCATION
13q32.2
LOCUSID
3843
ALIAS
IMB3,KPNB3,Pse1,RANBP5,imp5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3843
MIM: 602008
HGNC: 6402
Ensembl: ENSG00000065150

Variants:

dbSNP: 3843
ClinVar: 3843
TCGA: ENSG00000065150
COSMIC: IPO5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065150ENST00000261574O00410
ENSG00000065150ENST00000357602O00410
ENSG00000065150ENST00000357602A0A024RDY0
ENSG00000065150ENST00000403772H0Y3V4
ENSG00000065150ENST00000421861E7ESZ1
ENSG00000065150ENST00000460070E7EV12
ENSG00000065150ENST00000463157C9JQT6
ENSG00000065150ENST00000469360H0Y8C6
ENSG00000065150ENST00000471898C9JZD8
ENSG00000065150ENST00000475420E7ETV3
ENSG00000065150ENST00000480611E7EWK4
ENSG00000065150ENST00000480641C9JZ53
ENSG00000065150ENST00000481455E7EX05
ENSG00000065150ENST00000481689E7ETV8
ENSG00000065150ENST00000485433C9J875
ENSG00000065150ENST00000489058C9J583
ENSG00000065150ENST00000490369F8WF30
ENSG00000065150ENST00000490680O00410
ENSG00000065150ENST00000490680A0A024RDY0
ENSG00000065150ENST00000493281C9JXE0
ENSG00000065150ENST00000496368E7ETV8
ENSG00000065150ENST00000497270E7EQT5
ENSG00000065150ENST00000631030A0A0D9SG25
ENSG00000065150ENST00000651721O00410
ENSG00000065150ENST00000651721A0A024RDY0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
vRNP AssemblyREACTOMER-HSA-192905

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
322223842020X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.5
323739602020IPO5 promotes malignant progression of esophageal cancer through activating MMP7.6
322223842020X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.5
323739602020IPO5 promotes malignant progression of esophageal cancer through activating MMP7.6
312888612019IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.21
313409992019DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.10
312888612019IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.21
313409992019DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.10
291271992017The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation.8
291271992017The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation.8
270943872016Ebola virus encodes a miR-155 analog to regulate importin-α5 expression.21
275286062016Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.28
277030042016Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.7
270943872016Ebola virus encodes a miR-155 analog to regulate importin-α5 expression.21
275286062016Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.28

Citation

Dessen P

IPO5 (importin 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41102/humanGenome