Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3902
MIM: 153337
HGNC: 6476
Ensembl: ENSG00000089692
Variants:
dbSNP: 3902
ClinVar: 3902
TCGA: ENSG00000089692
COSMIC: LAG3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000089692 | ENST00000203629 | P18627 |
| ENSG00000089692 | ENST00000441671 | P18627 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| MHC class II antigen presentation | REACTOME | R-HSA-2132295 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36918273 | 2024 | Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients. | 3 |
| 37855027 | 2024 | Multiplex immunohistochemistry elucidates increased distance between cytotoxic T cells and plasma cells in relapsed myeloma, and identifies Lag-3 as the most common checkpoint receptor on cytotoxic T cells of myeloma patients. | 0 |
| 37952520 | 2024 | LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma. | 1 |
| 38301597 | 2024 | Altered immune co-inhibitory receptor expression and correlation of LAG-3 expression to disease severity in NMOSD. | 0 |
| 38325197 | 2024 | Expression of lymphocyte activation gene-3 on CD4(+)T cells is regulated by cytokine interleukin-18 in myasthenia gravis. | 0 |
| 38792904 | 2024 | Association of Polymorphisms in PD-1 and LAG-3 Genes with Acute Myeloid Leukemia. | 0 |
| 38821932 | 2024 | Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein. | 0 |
| 36918273 | 2024 | Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients. | 3 |
| 37855027 | 2024 | Multiplex immunohistochemistry elucidates increased distance between cytotoxic T cells and plasma cells in relapsed myeloma, and identifies Lag-3 as the most common checkpoint receptor on cytotoxic T cells of myeloma patients. | 0 |
| 37952520 | 2024 | LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma. | 1 |
| 38301597 | 2024 | Altered immune co-inhibitory receptor expression and correlation of LAG-3 expression to disease severity in NMOSD. | 0 |
| 38325197 | 2024 | Expression of lymphocyte activation gene-3 on CD4(+)T cells is regulated by cytokine interleukin-18 in myasthenia gravis. | 0 |
| 38792904 | 2024 | Association of Polymorphisms in PD-1 and LAG-3 Genes with Acute Myeloid Leukemia. | 0 |
| 38821932 | 2024 | Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein. | 0 |
| 34651389 | 2023 | Overexpression of LAG3, TIM3, and A2aR in adenoid cystic carcinoma and mucoepidermoid carcinoma. | 1 |
Citation
Dessen P
LAG3 (lymphocyte activating 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41111/lag3-(lymphocyte-activating-3)
