LGMN (legumain)

2003-08-01 Affiliation

Identity

HGNC

LGMN

LOCATION

14q32.12

LOCUSID

5641

ALIAS

AEP,LGMN1,PRSC1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5641
MIM: 602620
HGNC: 9472
Ensembl: ENSG00000100600

Variants:

dbSNP: 5641
ClinVar: 5641
TCGA: ENSG00000100600
COSMIC: LGMN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100600	ENST00000334869	Q99538
ENSG00000100600	ENST00000334869	Q53XC6
ENSG00000100600	ENST00000393218	Q99538
ENSG00000100600	ENST00000393218	Q53XC6
ENSG00000100600	ENST00000553371	G3V5B2
ENSG00000100600	ENST00000553802	G3V2T4
ENSG00000100600	ENST00000553918	G3V2E9
ENSG00000100600	ENST00000554080	G3V5B2
ENSG00000100600	ENST00000554189	G3V263
ENSG00000100600	ENST00000554397	G3V4P5
ENSG00000100600	ENST00000554919	G3V4P5
ENSG00000100600	ENST00000555169	H0YJN9
ENSG00000100600	ENST00000555699	Q99538
ENSG00000100600	ENST00000556097	G3V4E4
ENSG00000100600	ENST00000557434	Q99538
ENSG00000100600	ENST00000557609	G3V3Z4

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Antigen processing and presentation	KEGG	ko04612
Antigen processing and presentation	KEGG	hsa04612
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Trafficking and processing of endosomal TLR	REACTOME	R-HSA-1679131
Metabolism	REACTOME	R-HSA-1430728
Vitamin D (calciferol) metabolism	REACTOME	R-HSA-196791
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of fat-soluble vitamins	REACTOME	R-HSA-6806667

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25326800	2014	Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.	96
18374643	2008	Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.	50
26549211	2015	Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.	49
12860980	2003	Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.	48
23776206	2013	Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.	45
19453521	2009	GARP: a key receptor controlling FOXP3 in human regulatory T cells.	44
26403494	2016	Structure and function of legumain in health and disease.	38
23640887	2013	Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.	34
15788679	2005	Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer.	33
28671665	2017	Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.	30

Citation

Dessen P

LGMN (legumain)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41148/lgmn-(legumain)