LGMN (legumain)

2003-08-01  

Identity

HGNC
LGMN
LOCATION
14q32.12
LOCUSID
5641
ALIAS
AEP,LGMN1,PRSC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5641
MIM: 602620
HGNC: 9472
Ensembl: ENSG00000100600

Variants:

dbSNP: 5641
ClinVar: 5641
TCGA: ENSG00000100600
COSMIC: LGMN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100600ENST00000334869Q99538
ENSG00000100600ENST00000334869Q53XC6
ENSG00000100600ENST00000393218Q99538
ENSG00000100600ENST00000393218Q53XC6
ENSG00000100600ENST00000553371G3V5B2
ENSG00000100600ENST00000553802G3V2T4
ENSG00000100600ENST00000553918G3V2E9
ENSG00000100600ENST00000554080G3V5B2
ENSG00000100600ENST00000554189G3V263
ENSG00000100600ENST00000554397G3V4P5
ENSG00000100600ENST00000554919G3V4P5
ENSG00000100600ENST00000555169H0YJN9
ENSG00000100600ENST00000555699Q99538
ENSG00000100600ENST00000556097G3V4E4
ENSG00000100600ENST00000557434Q99538
ENSG00000100600ENST00000557609G3V3Z4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Antigen processing and presentationKEGGhsa04612
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
MetabolismREACTOMER-HSA-1430728
Vitamin D (calciferol) metabolismREACTOMER-HSA-196791
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
364641742023Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.2
366096512023Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer.0
379095382023Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque.1
379772232023c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.0
379881652023AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.3
380092312023Potential relevance of salivary legumain for the clinical diagnostic of hand, foot, and mouth disease.0
364641742023Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.2
366096512023Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer.0
379095382023Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque.1
379772232023c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.0
379881652023AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.3
380092312023Potential relevance of salivary legumain for the clinical diagnostic of hand, foot, and mouth disease.0
350534092022Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene.3
351005262022Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture.37
353323312022An infection-induced oxidation site regulates legumain processing and tumor growth.6

Citation

Dessen P

LGMN (legumain)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41148/lgmn-(legumain)