LHX4 (LIM homeobox 4)

2003-02-01  

Identity

HGNC
LHX4
LOCATION
1q25.2
LOCUSID
89884
ALIAS
CPHD4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 89884
MIM: 602146
HGNC: 21734
Ensembl: ENSG00000121454

Variants:

dbSNP: 89884
ClinVar: 89884
TCGA: ENSG00000121454
COSMIC: LHX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121454ENST00000263726Q969G2
ENSG00000121454ENST00000263726A0A0S2Z5S4
ENSG00000121454ENST00000561113H0YKF4

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
379485642023Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes.0
379485642023Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes.0
278206712017Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients.9
278206712017Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients.9
258718392015Novel Lethal Form of Congenital Hypopituitarism Associated With the First Recessive LHX4 Mutation.9
259551772015Identifying the Deleterious Effect of Rare LHX4 Allelic Variants, a Challenging Issue.5
258718392015Novel Lethal Form of Congenital Hypopituitarism Associated With the First Recessive LHX4 Mutation.9
259551772015Identifying the Deleterious Effect of Rare LHX4 Allelic Variants, a Challenging Issue.5
250345242014Oncogenicity of LHX4 in colorectal cancer through Wnt/β-catenin/TCF4 cascade.8
250345242014Oncogenicity of LHX4 in colorectal cancer through Wnt/β-catenin/TCF4 cascade.8
231991972013Pituitary stalk interruption syndrome in 58 Chinese patients: clinical features and genetic analysis.14
231991972013Pituitary stalk interruption syndrome in 58 Chinese patients: clinical features and genetic analysis.14
222323092012Panhypopituitarism presenting as life-threatening heart failure caused by an inherited microdeletion in 1q25 including LHX4.12
230293632012Gradual loss of ACTH due to a novel mutation in LHX4: comprehensive mutation screening in Japanese patients with congenital hypopituitarism.6
222323092012Panhypopituitarism presenting as life-threatening heart failure caused by an inherited microdeletion in 1q25 including LHX4.12

Citation

Dessen P

LHX4 (LIM homeobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41152/lhx4-(lim-homeobox-4)