LIF (LIF interleukin 6 family cytokine)

2003-02-01 Affiliation

Identity

HGNC

LIF

LOCATION

22q12.2

LOCUSID

3976

ALIAS

CDF,DIA,HILDA,MLPLI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3976
MIM: 159540
HGNC: 6596
Ensembl: ENSG00000128342

Variants:

dbSNP: 3976
ClinVar: 3976
TCGA: ENSG00000128342
COSMIC: LIF

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000128342	ENST00000249075	P15018
ENSG00000128342	ENST00000403987	P15018

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-6 family signaling	REACTOME	R-HSA-6783589
IL-6-type cytokine receptor ligand interactions	REACTOME	R-HSA-6788467
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807
Interleukin-10 signaling	REACTOME	R-HSA-6783783

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17848619	2007	Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells.	116
15342941	2004	LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells.	110
12218157	2002	IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae.	98
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19470478	2009	Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.	66
19011087	2008	Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression.	65
26187859	2015	Leukemia inhibitory factor (LIF).	63
24270418	2013	Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance.	53
24857661	2014	LIF mediates proinvasive activation of stromal fibroblasts in cancer.	50
25323535	2014	LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.	50

Citation

Dessen P

LIF (LIF interleukin 6 family cytokine)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41153/lif-(lif-interleukin-6-family-cytokine)