Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3978
MIM: 126391
HGNC: 6598
Ensembl: ENSG00000105486
Variants:
dbSNP: 3978
ClinVar: 3978
TCGA: ENSG00000105486
COSMIC: LIG1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38522520 | 2024 | Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA. | 1 |
| 38522520 | 2024 | Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA. | 1 |
| 36625284 | 2023 | Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. | 1 |
| 36928068 | 2023 | Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. | 2 |
| 37369482 | 2023 | The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese. | 2 |
| 36625284 | 2023 | Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. | 1 |
| 36928068 | 2023 | Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. | 2 |
| 37369482 | 2023 | The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese. | 2 |
| 33444456 | 2021 | LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. | 10 |
| 33600799 | 2021 | DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair. | 10 |
| 34373746 | 2021 | Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers. | 10 |
| 33444456 | 2021 | LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. | 10 |
| 33600799 | 2021 | DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair. | 10 |
| 34373746 | 2021 | Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers. | 10 |
| 31630206 | 2020 | Altered DNA ligase activity in human disease. | 16 |
Citation
Dessen P
LIG1 (DNA ligase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41154/lig1-(dna-ligase-1)
