LIG3 (DNA ligase 3)

2003-02-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
LIG2,LIG3alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 3980
MIM: 600940
HGNC: 6600
Ensembl: ENSG00000005156

Variants:

dbSNP: 3980
ClinVar: 3980
TCGA: ENSG00000005156
COSMIC: LIG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005156ENST00000262327P49916
ENSG00000005156ENST00000378526P49916
ENSG00000005156ENST00000585370K7EJR4
ENSG00000005156ENST00000585740K7EQB6
ENSG00000005156ENST00000585941K7ERZ5
ENSG00000005156ENST00000588109K7ELY6
ENSG00000005156ENST00000592690K7ENR9

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
BER complexKEGGhsa_M00296
BER complexKEGGM00296
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the single-nucleotide replacement pathwayREACTOMER-HSA-110381
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayREACTOMER-HSA-5649702
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through MMEJ (alt-NHEJ)REACTOMER-HSA-5685939
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD24533712
PA449014cisplatinChemicalClinicalAnnotationassociatedPD24533712
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD24533712

References

Pubmed IDYearTitleCitations
193054082009Common variants at ten loci influence QT interval duration in the QTGEN Study.190
176433792007Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner.115
161952372006Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.112
213901322011Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair.93
102071101999The human DNA ligase III gene encodes nuclear and mitochondrial proteins.83
183133852008CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.74
166090222006Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.71
185249932008Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.66
152053552004Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

LIG3 (DNA ligase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41155/lig3-(dna-ligase-3)