Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3980
MIM: 600940
HGNC: 6600
Ensembl: ENSG00000005156
Variants:
dbSNP: 3980
ClinVar: 3980
TCGA: ENSG00000005156
COSMIC: LIG3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation | associated | PD | 24533712 | |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD | 24533712 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | 24533712 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36625284 | 2023 | Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. | 1 |
| 36988399 | 2023 | Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer. | 0 |
| 36625284 | 2023 | Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. | 1 |
| 36988399 | 2023 | Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer. | 0 |
| 33330937 | 2021 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex. | 19 |
| 33855352 | 2021 | Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy. | 23 |
| 34239347 | 2021 | Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis. | 7 |
| 33330937 | 2021 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex. | 19 |
| 33855352 | 2021 | Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy. | 23 |
| 34239347 | 2021 | Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis. | 7 |
| 31630206 | 2020 | Altered DNA ligase activity in human disease. | 16 |
| 33087274 | 2020 | Human DNA ligases in replication and repair. | 16 |
| 31630206 | 2020 | Altered DNA ligase activity in human disease. | 16 |
| 33087274 | 2020 | Human DNA ligases in replication and repair. | 16 |
| 30120376 | 2019 | miR-22 suppresses DNA ligase III addiction in multiple myeloma. | 28 |
Citation
Dessen P
LIG3 (DNA ligase 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41155/lig3-(dna-ligase-3)
