Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3981
MIM: 601837
HGNC: 6601
Ensembl: ENSG00000174405
Variants:
dbSNP: 3981
ClinVar: 3981
TCGA: ENSG00000174405
COSMIC: LIG4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38148049 | 2024 | The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer. | 0 |
| 38351293 | 2024 | Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct. | 1 |
| 38148049 | 2024 | The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer. | 0 |
| 38351293 | 2024 | Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct. | 1 |
| 37004747 | 2023 | Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency. | 0 |
| 37500161 | 2023 | The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer. | 1 |
| 37871849 | 2023 | Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics. | 0 |
| 37004747 | 2023 | Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency. | 0 |
| 37500161 | 2023 | The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer. | 1 |
| 37871849 | 2023 | Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics. | 0 |
| 35773772 | 2022 | [Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma]. | 0 |
| 35773772 | 2022 | [Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma]. | 0 |
| 33586762 | 2021 | Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability. | 0 |
| 34352203 | 2021 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. | 43 |
| 34614178 | 2021 | USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing. | 9 |
Citation
Dessen P
LIG4 (DNA ligase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41156/lig4-(dna-ligase-4)
