Identity
HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
DLG4,HUGL,HUGL-1,HUGL1,LLGL,Lgl1,Mgl1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3996
MIM: 600966
HGNC: 6628
Ensembl: ENSG00000131899
Variants:
dbSNP: 3996
ClinVar: 3996
TCGA: ENSG00000131899
COSMIC: LLGL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000131899 | ENST00000316843 | Q15334 |
| ENSG00000131899 | ENST00000621229 | A0A087WW77 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Tight junction | KEGG | ko04530 |
| Tight junction | KEGG | hsa04530 |
| Hippo signaling pathway | KEGG | hsa04390 |
| Hippo signaling pathway | KEGG | ko04390 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34717957 | 2021 | Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl. | 2 |
| 34717957 | 2021 | Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl. | 2 |
| 32222154 | 2020 | [MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1]. | 4 |
| 32615164 | 2020 | LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma. | 13 |
| 32697665 | 2020 | Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration. | 5 |
| 32222154 | 2020 | [MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1]. | 4 |
| 32615164 | 2020 | LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma. | 13 |
| 32697665 | 2020 | Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration. | 5 |
| 31058107 | 2019 | Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases. | 4 |
| 31058107 | 2019 | Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases. | 4 |
| 28628235 | 2017 | Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients. | 99 |
| 28628235 | 2017 | Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients. | 99 |
| 25982280 | 2016 | Scribble acts as an oncogene in Eμ-myc-driven lymphoma. | 9 |
| 26934648 | 2016 | MiR-652-3p is upregulated in non-small cell lung cancer and promotes proliferation and metastasis by directly targeting Lgl1. | 27 |
| 27542214 | 2016 | Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. | 4 |
Citation
Dessen P
LLGL1 (LLGL scribble cell polarity complex component 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41162/llgl1-(llgl-scribble-cell-polarity-complex-component-1)
