METTL21A (methyltransferase 21A, HSPA lysine)

2003-06-01  

Identity

HGNC
METTL21A
LOCATION
2q33.3
LOCUSID
151194
ALIAS
FAM119A,HCA557b,HSPA-KMT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 151194
MIM: 615257
HGNC: 30476
Ensembl: ENSG00000144401

Variants:

dbSNP: 151194
ClinVar: 151194
TCGA: ENSG00000144401
COSMIC: METTL21A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144401ENST00000272839H7BXH9
ENSG00000144401ENST00000406927Q8WXB1
ENSG00000144401ENST00000411432Q8WXB1
ENSG00000144401ENST00000425132Q8WXB1
ENSG00000144401ENST00000426075Q8WXB1
ENSG00000144401ENST00000432416C9JES0
ENSG00000144401ENST00000442521Q8WXB1
ENSG00000144401ENST00000448007Q8WXB1
ENSG00000144401ENST00000448823C9JSX1
ENSG00000144401ENST00000458426Q8WXB1

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447278DepressionDiseaseClinicalAnnotationassociatedPD17548750, 20643483
PA449015citalopramChemicalClinicalAnnotationassociatedPD17548750, 20643483
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD17548750, 20643483

References

Pubmed IDYearTitleCitations
233496342013A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.97
239213882013Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.65
233496342013A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.97
239213882013Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.65

Citation

Dessen P

METTL21A (methyltransferase 21A, HSPA lysine)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41173/mettl21a-(methyltransferase-21a-hspa-lysine)