LSM1 (LSM1 homolog, mRNA degradation associated)

2003-02-01  

Identity

HGNC
LSM1
LOCATION
8p11.23
LOCUSID
27257
ALIAS
CASM,YJL124C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27257
MIM: 607281
HGNC: 20472
Ensembl: ENSG00000175324

Variants:

dbSNP: 27257
ClinVar: 27257
TCGA: ENSG00000175324
COSMIC: LSM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175324ENST00000311351O15116
ENSG00000175324ENST00000311351A0A0S2Z590
ENSG00000175324ENST00000520755E5RH18
ENSG00000175324ENST00000523511E5RJ47

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Lsm 1-7 complexKEGGhsa_M00397
Lsm 1-7 complexKEGGM00397
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

References

Pubmed IDYearTitleCitations
379958952023The role of LSM1 in breast cancer: Shaping metabolism and tumor-associated macrophage infiltration.5
379958952023The role of LSM1 in breast cancer: Shaping metabolism and tumor-associated macrophage infiltration.5
356920832022Integrated analysis of pivotal biomarker of LSM1, immune cell infiltration and therapeutic drugs in breast cancer.7
356920832022Integrated analysis of pivotal biomarker of LSM1, immune cell infiltration and therapeutic drugs in breast cancer.7
323748712020DIS3L2 and LSm proteins are involved in the surveillance of Sm ring-deficient snRNAs.8
323748712020DIS3L2 and LSm proteins are involved in the surveillance of Sm ring-deficient snRNAs.8
258724762015LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.10
258724762015LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.10
240355622013Further evidence for the association between the LSM1 gene and schizophrenia.1
240355622013Further evidence for the association between the LSM1 gene and schizophrenia.1
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
182189952008CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.20
182189952008CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.20
170013082007Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon.33

Citation

Dessen P

LSM1 (LSM1 homolog, mRNA degradation associated)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41208/tumors-explorer/css/hgnc