Identity
HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
ARCL1C,LTBP-4,LTBP4L,LTBP4S
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8425
MIM: 604710
HGNC: 6717
Ensembl: ENSG00000090006
Variants:
dbSNP: 8425
ClinVar: 8425
TCGA: ENSG00000090006
COSMIC: LTBP4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Elastic fibre formation | REACTOME | R-HSA-1566948 |
| Molecules associated with elastic fibres | REACTOME | R-HSA-2129379 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38547642 | 2024 | Novel indel variation of LTBP4 gene associates with risk of sudden cardiac death in Chinese populations with coronary artery disease. | 1 |
| 38547642 | 2024 | Novel indel variation of LTBP4 gene associates with risk of sudden cardiac death in Chinese populations with coronary artery disease. | 1 |
| 35708897 | 2023 | Specific Overexpression of YAP in Vascular Smooth Muscle Attenuated Abdominal Aortic Aneurysm Formation by Activating Elastic Fiber Assembly via LTBP4. | 2 |
| 37232163 | 2023 | LTBP4 Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts. | 3 |
| 35708897 | 2023 | Specific Overexpression of YAP in Vascular Smooth Muscle Attenuated Abdominal Aortic Aneurysm Formation by Activating Elastic Fiber Assembly via LTBP4. | 2 |
| 37232163 | 2023 | LTBP4 Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts. | 3 |
| 34958866 | 2022 | Aberrant interaction between mutated ADAMTSL2 and LTBP4 is associated with adolescent idiopathic scoliosis. | 3 |
| 36011296 | 2022 | LTBP4, SPP1, and CD40 Variants: Genetic Modifiers of Duchenne Muscular Dystrophy Analyzed in Serbian Patients. | 2 |
| 36524797 | 2022 | Association of polymorphisms rs2303729, rs10880, and rs1131620 of LTBP4 with sarcopenia in elderly patients with type 2 diabetes mellitus. | 0 |
| 34958866 | 2022 | Aberrant interaction between mutated ADAMTSL2 and LTBP4 is associated with adolescent idiopathic scoliosis. | 3 |
| 36011296 | 2022 | LTBP4, SPP1, and CD40 Variants: Genetic Modifiers of Duchenne Muscular Dystrophy Analyzed in Serbian Patients. | 2 |
| 36524797 | 2022 | Association of polymorphisms rs2303729, rs10880, and rs1131620 of LTBP4 with sarcopenia in elderly patients with type 2 diabetes mellitus. | 0 |
| 34645813 | 2021 | LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure. | 7 |
| 34645813 | 2021 | LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure. | 7 |
| 32658840 | 2020 | Serum latent transforming growth factor-β binding protein 4 as a novel biomarker for idiopathic pleuroparenchymal fibroelastosis. | 3 |
Citation
Dessen P
LTBP4 (latent transforming growth factor beta binding protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/41215/ltbp4-(latent-transforming-growth-factor-beta-binding-protein-4)
