LY6E (lymphocyte antigen 6 family member E)

2003-11-01 Affiliation

Identity

HGNC

LY6E

LOCATION

8q24.3

LOCUSID

4061

ALIAS

RIG-E,RIGE,SCA-2,SCA2,TSA-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4061
MIM: 601384
HGNC: 6727
Ensembl: ENSG00000160932

Variants:

dbSNP: 4061
ClinVar: 4061
TCGA: ENSG00000160932
COSMIC: LY6E

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160932	ENST00000292494	Q16553
ENSG00000160932	ENST00000429120	Q16553
ENSG00000160932	ENST00000517503	E7EWF8
ENSG00000160932	ENST00000519546	E5RI33
ENSG00000160932	ENST00000519611	E5RI33
ENSG00000160932	ENST00000520466	Q16553
ENSG00000160932	ENST00000520531	E5RGI6
ENSG00000160932	ENST00000521003	Q16553
ENSG00000160932	ENST00000521182	E5RI58
ENSG00000160932	ENST00000521699	Q16553
ENSG00000160932	ENST00000522024	Q16553
ENSG00000160932	ENST00000522528	E5RI58
ENSG00000160932	ENST00000522971	Q16553
ENSG00000160932	ENST00000523847	E5RIQ1

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125

References

Pubmed ID	Year	Title	Citations
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
27197181	2016	Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance.	19
30190477	2018	LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.	18
25225669	2014	IFN-stimulated gene LY6E in monocytes regulates the CD14/TLR4 pathway but inadequately restrains the hyperactivation of monocytes during chronic HIV-1 infection.	17
18990604	2009	Intrafamilial variability of Parkinson phenotype in SCAs: novel cases due to SCA2 and SCA3 expansions.	16
18755862	2008	Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients.	15
25344775	2015	Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus.	14
27589564	2016	LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.	10
19672991	2009	Analysis of SCA2 and SCA3/MJD repeats in Parkinson's disease in mainland China: genetic, clinical, and positron emission tomography findings.	8
28130445	2017	Interferon-inducible LY6E Protein Promotes HIV-1 Infection.	7

Citation

Dessen P

LY6E (lymphocyte antigen 6 family member E)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41220/ly6e-(lymphocyte-antigen-6-family-member-e)