LYN (LYN proto-oncogene, Src family tyrosine kinase)

2003-02-01  

Identity

HGNC
LOCATION
8q12.1
LOCUSID
ALIAS
JTK8,p53Lyn,p56Lyn
FUSION GENES

Other Information

Locus ID:

NCBI: 4067
MIM: 165120
HGNC: 6735
Ensembl: ENSG00000254087

Variants:

dbSNP: 4067
ClinVar: 4067
TCGA: ENSG00000254087
COSMIC: LYN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000254087ENST00000519728P07948
ENSG00000254087ENST00000520050E5RJ37
ENSG00000254087ENST00000520220P07948

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
B cell receptor signaling pathwayKEGGko04662
Fc epsilon RI signaling pathwayKEGGko04664
Long-term depressionKEGGko04730
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
B cell receptor signaling pathwayKEGGhsa04662
Fc epsilon RI signaling pathwayKEGGhsa04664
Long-term depressionKEGGhsa04730
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
CTLA4 inhibitory signalingREACTOMER-HSA-389513
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
FCERI mediated NF-kB activationREACTOMER-HSA-2871837
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Regulation of signaling by CBLREACTOMER-HSA-912631
Growth hormone receptor signalingREACTOMER-HSA-982772
HemostasisREACTOMER-HSA-109582
Platelet Adhesion to exposed collagenREACTOMER-HSA-75892
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
PECAM1 interactionsREACTOMER-HSA-210990
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557
Regulation of KIT signalingREACTOMER-HSA-1433559
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPHB-mediated forward signalingREACTOMER-HSA-3928662
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665
CD22 mediated BCR regulationREACTOMER-HSA-5690714

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388103202024A novel lncRNA associated with the prognosis of patients with colorectal cancer resists apoptosis through the LYN/BCL-2 pathway.0
388103202024A novel lncRNA associated with the prognosis of patients with colorectal cancer resists apoptosis through the LYN/BCL-2 pathway.0
367249042023Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug Resistance (MDR1) gene.1
368990052023LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1.4
369320762023Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.6
370141382023Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer.3
367249042023Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug Resistance (MDR1) gene.1
368990052023LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1.4
369320762023Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.6
370141382023Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer.3
360589992022Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer.4
360589992022Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer.4
331998372021Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model.2
335124742021CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.13
331998372021Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model.2

Citation

Dessen P

LYN (LYN proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41221/lyn-(lyn-proto-oncogene-src-family-tyrosine-kinase)