Identity
HGNC
LOCATION
15q22.33
LOCUSID
ALIAS
HSPC193,HsT17436,JV15-2,LDS1C,LDS3,MADH3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4088
MIM: 603109
HGNC: 6769
Ensembl: ENSG00000166949
Variants:
dbSNP: 4088
ClinVar: 4088
TCGA: ENSG00000166949
COSMIC: SMAD3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA161907438 | Thoracic Aortic Aneurysms and Dissections (TAAD) | Disease | DataAnnotation | associated | |||
| PA166123310 | loeys-dietz syndrome | Disease | DataAnnotation | associated | |||
| PA24456 | ACTA2 | Gene | DataAnnotation | associated | |||
| PA28016 | FBN1 | Gene | DataAnnotation | associated | |||
| PA31367 | MYH11 | Gene | DataAnnotation | associated | |||
| PA31388 | MYLK | Gene | DataAnnotation | associated | |||
| PA36485 | TGFBR1 | Gene | DataAnnotation | associated | |||
| PA36486 | TGFBR2 | Gene | DataAnnotation | associated | |||
| PA444880 | Marfan Syndrome | Disease | DataAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37739089 | 2024 | BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma. | 3 |
| 37921754 | 2024 | Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats. | 2 |
| 38061486 | 2024 | POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis. | 0 |
| 38066678 | 2024 | Investigating dysregulation of TGF-β1/SMAD3 signaling in atopic dermatitis: a molecular and immunohistochemical analysis. | 1 |
| 38088865 | 2024 | Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes. | 0 |
| 38093516 | 2024 | Therapeutic potential for renal fibrosis by targeting Smad3-dependent noncoding RNAs. | 0 |
| 38141763 | 2024 | The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation. | 3 |
| 38383842 | 2024 | MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer. | 0 |
| 38453045 | 2024 | TGF-β1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma. | 1 |
| 38493128 | 2024 | Single-cell transcriptomic sequencing data reveal aberrant DNA methylation in SMAD3 promoter region in tumor-associated fibroblasts affecting molecular mechanism of radiosensitivity in non-small cell lung cancer. | 0 |
| 38495810 | 2024 | DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways. | 0 |
| 38527804 | 2024 | Linc00673-V3 positively regulates autophagy by promoting Smad3-mediated LC3B transcription in NSCLC. | 0 |
| 38789630 | 2024 | Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway. | 0 |
| 37739089 | 2024 | BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma. | 3 |
| 37921754 | 2024 | Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats. | 2 |
Citation
Dessen P
SMAD3 (SMAD family member 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41229/smad3-(smad-family-member-3)
