MAFK (MAF bZIP transcription factor K)

2003-11-01 Affiliation

Identity

HGNC

MAFK

LOCATION

7p22.3

LOCUSID

7975

ALIAS

NFE2U,P18

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7975
MIM: 600197
HGNC: 6782
Ensembl: ENSG00000198517

Variants:

dbSNP: 7975
ClinVar: 7975
TCGA: ENSG00000198517
COSMIC: MAFK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198517	ENST00000343242	O60675
ENSG00000198517	ENST00000343242	A0A024R804
ENSG00000198517	ENST00000403150	O60675
ENSG00000198517	ENST00000403150	A0A024R804
ENSG00000198517	ENST00000406174	O60675
ENSG00000198517	ENST00000406174	A0A024R804

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated	PD	22341855, 29036176
PA166119041	drug-induced liver injury	Disease	ClinicalAnnotation	associated	PD	22341855, 29036176
PA283	MAPK8	Gene	Pathway	associated		23922006
PA30621	MAPK14	Gene	Pathway	associated		23922006
PA450112	isoniazid	Chemical	ClinicalAnnotation	associated	PD	22341855, 29036176

References

Pubmed ID	Year	Title	Citations
35260530	2022	MafK accelerates Salmonella mucosal infection through caspase-3 activation.	2
35260530	2022	MafK accelerates Salmonella mucosal infection through caspase-3 activation.	2
33877894	2021	MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa.	0
33877894	2021	MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa.	0
28400538	2017	The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.	40
28839436	2017	Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan.	2
28400538	2017	The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.	40
28839436	2017	Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan.	2
26214410	2015	Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.	8
26214410	2015	Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.	8
23737527	2013	Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.	28
24232097	2013	Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.	27
24247732	2013	MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation.	29
23737527	2013	Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.	28
24232097	2013	Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.	27

Citation

Dessen P

MAFK (MAF bZIP transcription factor K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41239/cancer-prone-explorer/deep-insight-explorer/humanGenome